This gene encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains. The encoded protein plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands. Expression of this gene may play a role in the tumorigenesis and metastasis of several malignancies including breast cancer, gliomas and metastatic bone disease. [provided by RefSeq, Feb 2012]
Transcription factors with Perturb-seq knockdown data for MRC2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MRC2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MRC2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:62,423,543–62,424,436 | 203.8 kb | Distal (>10kb) Multiome | 604 | |
| chr17:62,477,989–62,479,448 | 149.0 kb | Distal (>10kb) Multiome | 323 | |
| chr17:62,617,005–62,618,105 | 10.2 kb | Distal (>10kb) Multiome | 481 | |
| chr17:62,625,629–62,626,248 | 1.4 kb | Proximal (<10kb) | 60 | |
| chr17:62,626,684–62,628,608 | 204 bp | At TSS Multiome | 557 | |
| chr17:62,628,899–62,629,683 | 1.2 kb | Proximal (<10kb) | 135 | |
| chr17:62,633,691–62,633,854 | 6.0 kb | Proximal (<10kb) | 102 | |
| chr17:62,652,264–62,654,102 | 25.7 kb | Distal (>10kb) Multiome | 643 | |
| chr17:62,703,431–62,705,528 | 76.3 kb | Distal (>10kb) Multiome | 653 | |
| chr17:62,705,630–62,706,390 | 78.3 kb | Distal (>10kb) Multiome | 153 | |
| chr17:62,807,913–62,808,572 | 180.6 kb | Distal (>10kb) Multiome | 313 |
Genomic view of the MRC2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.