Involved in positive regulation of double-strand break repair via homologous recombination and regulation of cell cycle. Located in nucleolus; nucleoplasm; and plasma membrane. Part of NuA4 histone acetyltransferase complex and nucleosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MORF4L2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MORF4L2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MORF4L2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:103,431,896–103,432,874 | 255.7 kb | Distal (>10kb) Multiome | 6 | |
| chrX:103,607,566–103,608,355 | 80.0 kb | Distal (>10kb) Multiome | 234 | |
| chrX:103,686,434–103,687,597 | 1.1 kb | Proximal (<10kb) Multiome | 737 | |
| chrX:103,687,715–103,688,193 | 1.0 kb | Proximal (<10kb) | 411 | |
| chrX:103,697,428–103,698,088 | 9.4 kb | Proximal (<10kb) | 25 | |
| chrX:103,766,973–103,767,614 | 79.2 kb | Distal (>10kb) Multiome | 82 | |
| chrX:103,831,529–103,832,547 | 144.0 kb | Distal (>10kb) Multiome | 250 | |
| chrX:103,918,585–103,919,659 | 231.2 kb | Distal (>10kb) Multiome | 303 |
Genomic view of the MORF4L2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.