Transcription factors with Perturb-seq knockdown data for MIRLET7IHG. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MIRLET7IHG upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MIRLET7IHG, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:62,435,134–62,436,513 | 166.9 kb | Distal (>10kb) Multiome | 442 | |
| chr12:62,466,179–62,467,402 | 136.0 kb | Distal (>10kb) Multiome | 866 | |
| chr12:62,602,250–62,603,979 | 54 bp | At TSS Multiome | 1165 | |
| chr12:62,604,879–62,605,185 | 2.1 kb | Proximal (<10kb) | 93 | |
| chr12:62,606,116–62,606,362 | 3.4 kb | Proximal (<10kb) | 40 | |
| chr12:62,606,578–62,607,129 | 3.8 kb | Proximal (<10kb) | 53 | |
| chr12:62,608,556–62,609,392 | 5.8 kb | Proximal (<10kb) | 34 | |
| chr12:62,609,917–62,610,248 | 7.2 kb | Proximal (<10kb) | 15 | |
| chr12:62,610,632–62,611,303 | 7.9 kb | Proximal (<10kb) | 10 | |
| chr12:62,611,447–62,611,794 | 8.7 kb | Proximal (<10kb) | 3 | |
| chr12:62,611,911–62,612,510 | 9.2 kb | Proximal (<10kb) | 11 | |
| chr12:62,646,389–62,647,205 | 44.0 kb | Distal (>10kb) Multiome | 78 | |
| chr12:62,653,374–62,655,092 | 51.3 kb | Distal (>10kb) Multiome | 290 | |
| chr12:62,659,395–62,659,972 | 56.9 kb | Distal (>10kb) Multiome | 177 | |
| chr12:62,673,057–62,673,824 | 70.8 kb | Distal (>10kb) Multiome | 53 | |
| chr12:62,768,586–62,770,424 | 167.5 kb | Distal (>10kb) Multiome HiCAR | 179 | |
| chr12:62,792,786–62,794,262 | 190.7 kb | Distal (>10kb) Multiome HiCAR | 428 |
Genomic view of the MIRLET7IHG locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.