This gene encodes a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways. [provided by RefSeq, Mar 2016]
Transcription factors with Perturb-seq knockdown data for MINK1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MINK1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MINK1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:4,555,276–4,555,773 | 277.9 kb | Distal (>10kb) Multiome | 806 | |
| chr17:4,583,931–4,585,086 | 249.1 kb | Distal (>10kb) Multiome | 323 | |
| chr17:4,703,669–4,704,637 | 129.3 kb | Distal (>10kb) Multiome | 854 | |
| chr17:4,708,553–4,709,232 | 124.7 kb | Distal (>10kb) Multiome | 71 | |
| chr17:4,709,724–4,711,094 | 123.0 kb | Distal (>10kb) Multiome | 771 | |
| chr17:4,730,794–4,732,115 | 101.8 kb | Distal (>10kb) Multiome | 936 | |
| chr17:4,745,124–4,745,511 | 87.9 kb | Distal (>10kb) Multiome | 67 | |
| chr17:4,789,618–4,790,520 | 43.2 kb | Distal (>10kb) Multiome | 816 | |
| chr17:4,795,974–4,796,433 | 37.2 kb | Distal (>10kb) Multiome | 751 | |
| chr17:4,806,693–4,807,619 | 26.3 kb | Distal (>10kb) Multiome | 494 | |
| chr17:4,832,863–4,833,956 | 60 bp | At TSS Multiome | 730 | |
| chr17:4,898,962–4,900,112 | 66.1 kb | Distal (>10kb) Multiome | 257 | |
| chr17:4,900,249–4,901,057 | 67.4 kb | Distal (>10kb) Multiome | 145 | |
| chr17:4,909,117–4,909,538 | 75.8 kb | Distal (>10kb) Multiome | 553 | |
| chr17:4,939,475–4,941,034 | 106.8 kb | Distal (>10kb) Multiome | 821 | |
| chr17:4,947,426–4,950,636 | 116.8 kb | Distal (>10kb) Multiome | 1080 | |
| chr17:4,966,739–4,968,875 | 134.2 kb | Distal (>10kb) Multiome | 982 | |
| chr17:4,986,950–4,987,983 | 154.2 kb | Distal (>10kb) Multiome | 881 | |
| chr17:4,996,838–4,998,964 | 164.3 kb | Distal (>10kb) Multiome | 759 | |
| chr17:5,031,487–5,032,081 | 198.3 kb | Distal (>10kb) Multiome | 342 | |
| chr17:5,111,339–5,112,612 | 278.6 kb | Distal (>10kb) Multiome | 864 |
Genomic view of the MINK1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.