Predicted to enable K48-linked deubiquitinase activity. Predicted to be involved in protein K48-linked deubiquitination and proteolysis. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MINDY4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MINDY4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MINDY4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:30,472,499–30,473,444 | 298.5 kb | Distal (>10kb) Multiome | 123 | |
| chr7:30,478,426–30,479,128 | 292.7 kb | Distal (>10kb) Multiome | 756 | |
| chr7:30,504,202–30,505,455 | 266.5 kb | Distal (>10kb) Multiome | 824 | |
| chr7:30,544,196–30,544,698 | 226.9 kb | Distal (>10kb) Multiome | 40 | |
| chr7:30,594,119–30,595,511 | 176.5 kb | Distal (>10kb) Multiome | 1016 | |
| chr7:30,681,420–30,682,927 | 88.9 kb | Distal (>10kb) Multiome | 319 | |
| chr7:30,699,970–30,700,584 | 71.1 kb | Distal (>10kb) Multiome | 149 | |
| chr7:30,760,943–30,761,477 | 9.9 kb | Proximal (<10kb) | 278 | |
| chr7:30,771,029–30,771,985 | 75 bp | At TSS Multiome | 536 | |
| chr7:30,938,297–30,939,075 | 167.3 kb | Distal (>10kb) Multiome | 403 | |
| chr7:30,983,471–30,984,223 | 212.4 kb | Distal (>10kb) Multiome | 269 | |
| chr7:30,984,342–30,985,023 | 213.5 kb | Distal (>10kb) Multiome | 115 | |
| chr7:31,051,730–31,053,126 | 280.9 kb | Distal (>10kb) Multiome | 203 |
Genomic view of the MINDY4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.