This gene encodes a preproprotein that is proteolytically processed to form multiple protein products. The major encoded protein product, lactadherin, is a membrane glycoprotein that promotes phagocytosis of apoptotic cells. This protein has also been implicated in wound healing, autoimmune disease, and cancer. Lactadherin can be further processed to form a smaller cleavage product, medin, which comprises the major protein component of aortic medial amyloid (AMA). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
Transcription factors with Perturb-seq knockdown data for MFGE8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MFGE8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MFGE8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:88,612,843–88,613,762 | 300.1 kb | Distal (>10kb) Multiome | 214 | |
| chr15:88,614,278–88,615,021 | 298.7 kb | Distal (>10kb) Multiome | 414 | |
| chr15:88,620,659–88,621,775 | 292.2 kb | Distal (>10kb) Multiome | 829 | |
| chr15:88,638,306–88,639,588 | 274.5 kb | Distal (>10kb) Multiome | 1000 | |
| chr15:88,802,773–88,804,052 | 109.9 kb | Distal (>10kb) Multiome | 209 | |
| chr15:88,884,728–88,885,208 | 28.5 kb | Distal (>10kb) Multiome | 118 | |
| chr15:88,894,331–88,895,700 | 18.9 kb | Distal (>10kb) Multiome | 400 | |
| chr15:88,904,638–88,905,279 | 8.5 kb | Proximal (<10kb) Multiome | 420 | |
| chr15:88,911,834–88,912,158 | 1.3 kb | Proximal (<10kb) | 207 | |
| chr15:88,912,215–88,913,629 | 83 bp | At TSS Multiome | 632 | |
| chr15:88,982,989–88,983,702 | 69.8 kb | Distal (>10kb) Multiome HiCAR | 90 | |
| chr15:88,985,799–88,986,383 | 72.8 kb | Distal (>10kb) Multiome HiCAR | 269 | |
| chr15:88,987,948–88,988,725 | 74.9 kb | Distal (>10kb) Multiome HiCAR | 239 | |
| chr15:88,998,974–88,999,579 | 85.8 kb | Distal (>10kb) Multiome HiCAR | 139 | |
| chr15:89,017,417–89,018,078 | 104.3 kb | Distal (>10kb) Multiome HiCAR | 478 | |
| chr15:89,087,643–89,089,226 | 174.9 kb | Distal (>10kb) Multiome | 898 |
Genomic view of the MFGE8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.