This gene encodes a member of a family of proteins with two K homology (KH) RNA-binding domains and a C-terminal RING-finger domain. The protein interacts with mRNA via the KH domains, and the protein shuttles between the nucleus and cytoplasm. Polymorphisms in this gene may contribute to hypertension. [provided by RefSeq, Oct 2009]
Transcription factors with Perturb-seq knockdown data for MEX3C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MEX3C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MEX3C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:50,899,511–50,900,194 | 296.9 kb | Distal (>10kb) Multiome | 71 | |
| chr18:50,967,806–50,968,647 | 228.7 kb | Distal (>10kb) Multiome | 840 | |
| chr18:50,992,154–50,992,773 | 204.2 kb | Distal (>10kb) Multiome | 86 | |
| chr18:51,006,448–51,007,439 | 189.6 kb | Distal (>10kb) Multiome | 157 | |
| chr18:51,029,502–51,031,292 | 166.6 kb | Distal (>10kb) Multiome | 813 | |
| chr18:51,110,028–51,110,847 | 86.2 kb | Distal (>10kb) Multiome | 407 | |
| chr18:51,167,965–51,168,697 | 28.5 kb | Distal (>10kb) Multiome | 104 | |
| chr18:51,195,477–51,196,265 | 1.4 kb | Proximal (<10kb) | 383 | |
| chr18:51,196,412–51,198,613 | 1.1 kb | Proximal (<10kb) Multiome | 939 | |
| chr18:51,417,689–51,418,672 | 221.5 kb | Distal (>10kb) Multiome | 186 | |
| chr18:51,563,172–51,564,711 | 366.9 kb | Distal (>10kb) Multiome HiCAR | 187 | |
| chr18:51,573,769–51,574,737 | 377.4 kb | Distal (>10kb) Multiome HiCAR | 64 | |
| chr18:51,654,381–51,655,810 | 458.2 kb | Distal (>10kb) Multiome HiCAR | 282 | |
| chr18:51,656,346–51,657,395 | 460.1 kb | Distal (>10kb) Multiome HiCAR | 56 | |
| chr18:51,658,292–51,659,173 | 461.9 kb | Distal (>10kb) Multiome HiCAR | 167 | |
| chr18:51,659,299–51,660,300 | 463.3 kb | Distal (>10kb) Multiome HiCAR | 105 |
Genomic view of the MEX3C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.