The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MCM7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MCM7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MCM7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:99,839,578–99,840,069 | 261.6 kb | Distal (>10kb) Multiome | 85 | |
| chr7:99,929,116–99,929,724 | 171.9 kb | Distal (>10kb) Multiome | 300 | |
| chr7:100,015,387–100,016,069 | 85.8 kb | Distal (>10kb) Multiome | 744 | |
| chr7:100,049,441–100,050,060 | 51.6 kb | Distal (>10kb) Multiome | 800 | |
| chr7:100,081,134–100,083,000 | 19.5 kb | Distal (>10kb) Multiome | 1160 | |
| chr7:100,088,454–100,089,460 | 12.4 kb | Distal (>10kb) Multiome | 955 | |
| chr7:100,091,368–100,092,118 | 8.4 kb | Proximal (<10kb) | 283 | |
| chr7:100,100,270–100,102,380 | 762 bp | At TSS Multiome | 1102 | |
| chr7:100,119,029–100,120,415 | 18.1 kb | Distal (>10kb) Multiome HiCAR | 954 | |
| chr7:100,126,675–100,128,006 | 25.8 kb | Distal (>10kb) Multiome | 919 | |
| chr7:100,148,262–100,149,663 | 47.4 kb | Distal (>10kb) Multiome | 846 | |
| chr7:100,158,247–100,159,079 | 57.4 kb | Distal (>10kb) Multiome | 795 | |
| chr7:100,167,090–100,167,783 | 66.1 kb | Distal (>10kb) Multiome | 123 | |
| chr7:100,167,894–100,168,793 | 67.2 kb | Distal (>10kb) Multiome | 439 | |
| chr7:100,171,153–100,171,887 | 70.1 kb | Distal (>10kb) Multiome | 233 | |
| chr7:100,176,986–100,178,152 | 76.1 kb | Distal (>10kb) Multiome | 626 | |
| chr7:100,266,531–100,267,045 | 165.4 kb | Distal (>10kb) Multiome | 24 | |
| chr7:100,270,225–100,270,813 | 169.2 kb | Distal (>10kb) Multiome | 103 | |
| chr7:100,271,732–100,272,774 | 170.9 kb | Distal (>10kb) Multiome | 530 | |
| chr7:100,335,652–100,336,470 | 234.7 kb | Distal (>10kb) Multiome | 706 | |
| chr7:100,381,682–100,382,670 | 280.6 kb | Distal (>10kb) Multiome | 49 |
Genomic view of the MCM7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.