This gene encodes a member of the mitogen-activated protein kinase kinase kinase kinase family. The encoded protein activates key effectors in cell signalling, among them c-Jun. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Transcription factors with Perturb-seq knockdown data for MAP4K3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAP4K3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAP4K3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:39,227,946–39,229,047 | 208.9 kb | Distal (>10kb) Multiome | 489 | |
| chr2:39,243,540–39,245,159 | 193.3 kb | Distal (>10kb) Multiome | 277 | |
| chr2:39,300,512–39,301,961 | 135.7 kb | Distal (>10kb) Multiome | 183 | |
| chr2:39,364,530–39,365,418 | 72.2 kb | Distal (>10kb) Multiome | 145 | |
| chr2:39,434,384–39,434,594 | 2.6 kb | Proximal (<10kb) | 39 | |
| chr2:39,435,272–39,435,584 | 1.6 kb | Proximal (<10kb) | 100 | |
| chr2:39,436,378–39,438,239 | 1 bp | At TSS Multiome | 945 | |
| chr2:39,484,116–39,485,280 | 47.4 kb | Distal (>10kb) Multiome | 235 | |
| chr2:39,664,916–39,667,114 | 228.7 kb | Distal (>10kb) Multiome | 409 |
Genomic view of the MAP4K3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.