The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Transcription factors with Perturb-seq knockdown data for MAP4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAP4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAP4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:47,802,571–47,803,701 | 285.7 kb | Distal (>10kb) Multiome | 820 | |
| chr3:47,824,603–47,825,589 | 263.9 kb | Distal (>10kb) Multiome | 882 | |
| chr3:48,088,196–48,089,485 | 215 bp | At TSS Multiome | 933 | |
| chr3:48,187,500–48,188,989 | 99.7 kb | Distal (>10kb) Multiome | 820 | |
| chr3:48,240,728–48,241,473 | 152.3 kb | Distal (>10kb) Multiome | 843 | |
| chr3:48,300,947–48,301,746 | 212.6 kb | Distal (>10kb) Multiome | 954 | |
| chr3:48,372,864–48,373,543 | 284.4 kb | Distal (>10kb) Multiome | 49 |
Genomic view of the MAP4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.