The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus. [provided by RefSeq, Mar 2012]
Transcription factors with Perturb-seq knockdown data for MAP3K1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAP3K1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAP3K1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:56,814,407–56,817,107 | 129 bp | At TSS Multiome | 908 | |
| chr5:56,823,151–56,823,779 | 7.6 kb | Proximal (<10kb) | 65 | |
| chr5:56,909,110–56,910,601 | 94.3 kb | Distal (>10kb) Multiome | 974 | |
| chr5:56,950,605–56,952,748 | 136.7 kb | Distal (>10kb) Multiome | 662 | |
| chr5:57,019,246–57,020,109 | 204.2 kb | Distal (>10kb) Multiome | 80 | |
| chr5:57,070,146–57,071,232 | 255.2 kb | Distal (>10kb) Multiome | 102 | |
| chr5:57,095,125–57,095,719 | 279.9 kb | Distal (>10kb) Multiome | 128 |
Genomic view of the MAP3K1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.