Predicted to enable alpha-mannosidase activity. Predicted to be involved in N-glycan processing. Predicted to be located in Golgi apparatus and membrane. Predicted to be active in Golgi membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MAN2A2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAN2A2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAN2A2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:90,716,853–90,717,827 | 185.4 kb | Distal (>10kb) Multiome | 824 | |
| chr15:90,839,491–90,840,162 | 63.0 kb | Distal (>10kb) Multiome | 261 | |
| chr15:90,883,883–90,884,953 | 18.3 kb | Distal (>10kb) Multiome | 304 | |
| chr15:90,902,271–90,903,624 | 28 bp | At TSS Multiome | 817 | |
| chr15:90,903,843–90,904,131 | 1.1 kb | Proximal (<10kb) | 237 | |
| chr15:90,931,729–90,933,077 | 29.3 kb | Distal (>10kb) Multiome | 926 | |
| chr15:90,934,164–90,935,936 | 32.6 kb | Distal (>10kb) Multiome | 701 | |
| chr15:90,954,493–90,955,641 | 52.2 kb | Distal (>10kb) Multiome | 974 | |
| chr15:90,956,070–90,957,754 | 54.1 kb | Distal (>10kb) Multiome | 410 | |
| chr15:90,994,023–90,995,142 | 92.0 kb | Distal (>10kb) Multiome | 929 | |
| chr15:91,021,873–91,022,829 | 119.8 kb | Distal (>10kb) Multiome | 735 | |
| chr15:91,032,872–91,033,463 | 130.6 kb | Distal (>10kb) Multiome | 347 | |
| chr15:91,099,400–91,100,613 | 197.5 kb | Distal (>10kb) Multiome | 351 | |
| chr15:91,101,202–91,101,847 | 198.8 kb | Distal (>10kb) Multiome | 48 | |
| chr15:91,140,477–91,140,966 | 238.1 kb | Distal (>10kb) Multiome | 31 | |
| chr15:91,202,218–91,202,996 | 300.0 kb | Distal (>10kb) Multiome | 29 |
Genomic view of the MAN2A2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.