Drosophila that have mutations in their mago nashi (grandchildless) gene produce progeny with defects in germplasm assembly and germline development. This gene encodes the mammalian mago nashi homolog. In mammals, mRNA expression is not limited to the germ plasm, but is expressed ubiquitously in adult tissues and can be induced by serum stimulation of quiescent fibroblasts. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MAGOH. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAGOH upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAGOH, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:53,062,171–53,063,328 | 175.4 kb | Distal (>10kb) Multiome | 134 | |
| chr1:53,115,329–53,116,462 | 122.5 kb | Distal (>10kb) Multiome | 396 | |
| chr1:53,196,600–53,197,254 | 41.7 kb | Distal (>10kb) Multiome | 711 | |
| chr1:53,220,162–53,220,983 | 18.0 kb | Distal (>10kb) Multiome | 1003 | |
| chr1:53,238,114–53,239,137 | 103 bp | At TSS Multiome | 884 | |
| chr1:53,322,039–53,322,776 | 83.8 kb | Distal (>10kb) Multiome | 35 | |
| chr1:53,325,739–53,328,473 | 87.8 kb | Distal (>10kb) Multiome | 856 | |
| chr1:53,384,719–53,385,348 | 146.5 kb | Distal (>10kb) Multiome | 32 | |
| chr1:53,415,199–53,415,709 | 177.0 kb | Distal (>10kb) Multiome | 51 | |
| chr1:53,430,779–53,431,233 | 192.4 kb | Distal (>10kb) Multiome | 103 | |
| chr1:53,434,593–53,435,793 | 196.5 kb | Distal (>10kb) Multiome | 122 | |
| chr1:53,449,173–53,450,171 | 211.4 kb | Distal (>10kb) Multiome | 106 | |
| chr1:53,469,974–53,470,879 | 231.8 kb | Distal (>10kb) Multiome | 301 | |
| chr1:53,485,511–53,485,959 | 247.2 kb | Distal (>10kb) Multiome | 248 |
Genomic view of the MAGOH locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.