Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004]
Transcription factors with Perturb-seq knockdown data for LSM3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LSM3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LSM3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:13,879,719–13,881,081 | 298.2 kb | Distal (>10kb) Multiome | 324 | |
| chr3:13,894,956–13,896,282 | 283.3 kb | Distal (>10kb) Multiome HiCAR | 410 | |
| chr3:13,896,386–13,897,098 | 282.0 kb | Distal (>10kb) Multiome HiCAR | 240 | |
| chr3:13,947,416–13,948,575 | 230.9 kb | Distal (>10kb) Multiome | 105 | |
| chr3:13,950,690–13,951,954 | 227.5 kb | Distal (>10kb) Multiome | 157 | |
| chr3:14,121,816–14,122,532 | 56.7 kb | Distal (>10kb) Multiome | 97 | |
| chr3:14,124,108–14,126,323 | 53.9 kb | Distal (>10kb) Multiome | 1032 | |
| chr3:14,178,020–14,179,126 | 127 bp | At TSS Multiome | 960 | |
| chr3:14,216,206–14,216,677 | 37.6 kb | Distal (>10kb) Multiome | 226 | |
| chr3:14,232,409–14,233,221 | 54.0 kb | Distal (>10kb) Multiome | 527 | |
| chr3:14,272,392–14,272,931 | 93.9 kb | Distal (>10kb) Multiome | 132 | |
| chr3:14,319,426–14,320,088 | 141.0 kb | Distal (>10kb) Multiome | 332 | |
| chr3:14,401,899–14,403,672 | 223.7 kb | Distal (>10kb) Multiome | 895 | |
| chr3:14,412,856–14,413,790 | 234.6 kb | Distal (>10kb) Multiome | 270 | |
| chr3:14,463,118–14,463,686 | 284.6 kb | Distal (>10kb) Multiome HiCAR | 134 |
Genomic view of the LSM3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.