This gene encodes a member of the leucine-rich repeat-containing family of proteins, which function in diverse biological pathways. This family member may possibly be a nuclear protein. Similarity to the RAS suppressor protein, as well as expression down-regulation observed in tumor cells, suggests that it may function as a tumor suppressor. The gene is located in the chromosome 3 common eliminated region 1 (C3CER1), a 1.4 Mb region that is commonly deleted in diverse tumors. A related pseudogene has been identified on chromosome 2. [provided by RefSeq, Sep 2011]
Transcription factors with Perturb-seq knockdown data for LRRC2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LRRC2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LRRC2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:46,417,905–46,418,429 | 162.0 kb | Distal (>10kb) Multiome | 24 | |
| chr3:46,488,743–46,489,332 | 91.2 kb | Distal (>10kb) Multiome HiCAR | 616 | |
| chr3:46,558,406–46,558,641 | 7.7 kb | Proximal (<10kb) | 433 | |
| chr3:46,565,618–46,566,648 | 13.9 kb | Distal (>10kb) Multiome | 471 | |
| chr3:46,571,510–46,572,202 | 8.3 kb | Proximal (<10kb) Multiome | 22 | |
| chr3:46,573,613–46,576,275 | 5.7 kb | Proximal (<10kb) Multiome | 387 | |
| chr3:46,576,781–46,577,328 | 3.0 kb | Proximal (<10kb) Multiome | 158 | |
| chr3:46,586,733–46,587,577 | 6.6 kb | Proximal (<10kb) | 93 | |
| chr3:46,629,617–46,630,264 | 49.9 kb | Distal (>10kb) Multiome | 464 | |
| chr3:46,692,995–46,694,167 | 113.6 kb | Distal (>10kb) Multiome | 390 | |
| chr3:46,704,956–46,705,522 | 125.1 kb | Distal (>10kb) Multiome | 281 | |
| chr3:46,811,739–46,812,895 | 232.4 kb | Distal (>10kb) Multiome | 322 | |
| chr3:46,829,727–46,830,265 | 249.9 kb | Distal (>10kb) Multiome | 58 | |
| chr3:46,845,393–46,846,375 | 265.9 kb | Distal (>10kb) Multiome | 489 |
Genomic view of the LRRC2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.