Predicted to act upstream of or within cell population proliferation. Predicted to be located in intermediate filament and nucleus. Predicted to be active in cytoplasm and nuclear envelope. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for LMNTD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LMNTD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LMNTD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:25,384,448–25,387,046 | 244.5 kb | Distal (>10kb) Multiome | 1039 | |
| chr12:25,396,937–25,397,449 | 233.6 kb | Distal (>10kb) Multiome | 117 | |
| chr12:25,491,400–25,492,151 | 139.0 kb | Distal (>10kb) Multiome | 132 | |
| chr12:25,629,151–25,629,841 | 908 bp | At TSS | 34 | |
| chr12:25,630,300–25,631,420 | 143 bp | At TSS Multiome | 72 | |
| chr12:25,640,099–25,640,300 | 9.3 kb | Proximal (<10kb) | 7 | |
| chr12:25,648,528–25,648,832 | at TSS | At TSS | 212 | |
| chr12:25,876,360–25,876,912 | 246.0 kb | Distal (>10kb) Multiome | 39 |
Genomic view of the LMNTD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.