Transcription factors with Perturb-seq knockdown data for LINC02955. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LINC02955 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LINC02955, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:22,436,588–22,437,692 | 262.7 kb | Distal (>10kb) Multiome | 80 | |
| chr12:22,443,250–22,443,763 | 256.4 kb | Distal (>10kb) Multiome | 286 | |
| chr12:22,543,368–22,545,088 | 155.4 kb | Distal (>10kb) Multiome | 1040 | |
| chr12:22,624,339–22,626,265 | 74.8 kb | Distal (>10kb) Multiome | 1049 | |
| chr12:22,692,986–22,693,281 | 6.7 kb | Proximal (<10kb) | 62 | |
| chr12:22,699,795–22,700,629 | 41 bp | At TSS Multiome | 93 | |
| chr12:22,700,769–22,701,762 | 1.4 kb | Proximal (<10kb) Multiome | 149 | |
| chr12:22,709,385–22,709,605 | 9.4 kb | Proximal (<10kb) | 54 | |
| chr12:22,858,644–22,859,647 | 159.3 kb | Distal (>10kb) Multiome | 205 | |
| chr12:22,915,885–22,917,073 | 216.4 kb | Distal (>10kb) Multiome | 125 | |
| chr12:22,924,088–22,924,950 | 224.6 kb | Distal (>10kb) Multiome | 60 | |
| chr12:22,925,485–22,926,247 | 226.0 kb | Distal (>10kb) Multiome | 84 |
Genomic view of the LINC02955 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.