Transcription factors with Perturb-seq knockdown data for LINC01806. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LINC01806 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LINC01806, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:161,237,151–161,239,873 | 4.9 kb | Proximal (<10kb) | 760 | |
| chr2:161,243,171–161,243,817 | 920 bp | At TSS | 84 | |
| chr2:161,243,921–161,244,284 | 453 bp | At TSS | 59 | |
| chr2:161,244,441–161,245,204 | at TSS | At TSS | 383 | |
| chr2:161,245,319–161,245,670 | 581 bp | At TSS | 47 | |
| chr2:161,246,205–161,246,577 | 1.5 kb | Proximal (<10kb) | 60 | |
| chr2:161,250,938–161,251,242 | 6.2 kb | Proximal (<10kb) | 266 |
Genomic view of the LINC01806 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.