Transcription factors with Perturb-seq knockdown data for LINC01630. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LINC01630 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LINC01630, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:51,110,028–51,110,847 | 281.5 kb | Distal (>10kb) Multiome | 407 | |
| chr18:51,196,412–51,198,613 | 194.1 kb | Distal (>10kb) Multiome | 939 | |
| chr18:51,384,578–51,384,763 | 7.2 kb | Proximal (<10kb) | 54 | |
| chr18:51,563,172–51,564,711 | 171.6 kb | Distal (>10kb) Multiome | 187 | |
| chr18:51,573,769–51,574,737 | 182.2 kb | Distal (>10kb) Multiome | 64 | |
| chr18:51,610,172–51,611,019 | 218.6 kb | Distal (>10kb) Multiome | 106 | |
| chr18:51,654,381–51,655,810 | 263.0 kb | Distal (>10kb) Multiome | 282 | |
| chr18:51,656,346–51,657,395 | 264.9 kb | Distal (>10kb) Multiome | 56 | |
| chr18:51,658,292–51,659,173 | 266.7 kb | Distal (>10kb) Multiome | 167 | |
| chr18:51,659,299–51,660,300 | 268.0 kb | Distal (>10kb) Multiome | 105 |
Genomic view of the LINC01630 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.