Transcription factors with Perturb-seq knockdown data for LINC01586. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LINC01586 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LINC01586, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:88,388,191–88,389,364 | 216.3 kb | Distal (>10kb) Multiome | 280 | |
| chr15:88,467,068–88,468,013 | 137.6 kb | Distal (>10kb) Multiome | 857 | |
| chr15:88,537,723–88,539,073 | 66.4 kb | Distal (>10kb) Multiome | 141 | |
| chr15:88,545,733–88,547,888 | 58.6 kb | Distal (>10kb) Multiome | 818 | |
| chr15:88,571,230–88,572,235 | 33.4 kb | Distal (>10kb) Multiome | 149 | |
| chr15:88,600,505–88,600,760 | 4.3 kb | Proximal (<10kb) | 23 | |
| chr15:88,603,970–88,604,827 | 282 bp | At TSS | 122 | |
| chr15:88,604,930–88,605,917 | 605 bp | At TSS Multiome | 530 | |
| chr15:88,610,494–88,611,216 | 5.4 kb | Proximal (<10kb) | 201 | |
| chr15:88,612,843–88,613,762 | 8.2 kb | Proximal (<10kb) Multiome | 214 | |
| chr15:88,614,278–88,615,021 | 9.2 kb | Proximal (<10kb) | 414 | |
| chr15:88,620,659–88,621,775 | 16.1 kb | Distal (>10kb) Multiome | 829 | |
| chr15:88,638,306–88,639,588 | 33.8 kb | Distal (>10kb) Multiome | 1000 | |
| chr15:88,802,773–88,804,052 | 198.4 kb | Distal (>10kb) Multiome | 209 | |
| chr15:88,894,331–88,895,700 | 289.4 kb | Distal (>10kb) Multiome | 400 | |
| chr15:88,904,638–88,905,279 | 299.8 kb | Distal (>10kb) Multiome | 420 |
Genomic view of the LINC01586 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.