Transcription factors with Perturb-seq knockdown data for LINC01356. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LINC01356 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LINC01356, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:112,618,652–112,620,129 | 230.0 kb | Distal (>10kb) Multiome | 956 | |
| chr1:112,674,125–112,675,737 | 174.4 kb | Distal (>10kb) Multiome | 910 | |
| chr1:112,700,203–112,701,476 | 148.9 kb | Distal (>10kb) Multiome | 765 | |
| chr1:112,704,514–112,705,591 | 144.6 kb | Distal (>10kb) Multiome | 694 | |
| chr1:112,706,536–112,707,966 | 142.5 kb | Distal (>10kb) Multiome | 784 | |
| chr1:112,714,149–112,716,774 | 133.2 kb | Distal (>10kb) Multiome | 765 | |
| chr1:112,743,679–112,744,585 | 105.6 kb | Distal (>10kb) Multiome | 198 | |
| chr1:112,790,881–112,791,569 | 58.5 kb | Distal (>10kb) Multiome | 158 | |
| chr1:112,794,180–112,795,498 | 54.7 kb | Distal (>10kb) Multiome | 251 | |
| chr1:112,809,091–112,810,187 | 40.1 kb | Distal (>10kb) Multiome | 445 | |
| chr1:112,817,716–112,818,473 | 31.6 kb | Distal (>10kb) Multiome | 249 | |
| chr1:112,819,120–112,820,730 | 30.3 kb | Distal (>10kb) Multiome | 456 | |
| chr1:112,821,835–112,822,067 | 3.7 kb | Proximal (<10kb) | 41 | |
| chr1:112,822,500–112,823,067 | 2.7 kb | Proximal (<10kb) | 9 | |
| chr1:112,824,242–112,824,704 | 1.0 kb | Proximal (<10kb) | 6 | |
| chr1:112,825,474–112,826,954 | 23.9 kb | Distal (>10kb) Multiome | 182 | |
| chr1:112,827,333–112,827,686 | 1.6 kb | Proximal (<10kb) | 13 | |
| chr1:112,840,642–112,840,819 | 9.0 kb | Proximal (<10kb) | 82 | |
| chr1:112,841,024–112,841,798 | 8.4 kb | Proximal (<10kb) Multiome | 215 | |
| chr1:112,849,324–112,850,157 | 4 bp | At TSS Multiome | 352 | |
| chr1:112,852,305–112,852,574 | 2.5 kb | Proximal (<10kb) | 58 | |
| chr1:112,955,281–112,957,849 | 106.6 kb | Distal (>10kb) Multiome | 1108 | |
| chr1:113,040,180–113,041,009 | 190.7 kb | Distal (>10kb) Multiome HiCAR | 248 | |
| chr1:113,041,702–113,043,423 | 193.0 kb | Distal (>10kb) Multiome HiCAR | 544 | |
| chr1:113,043,627–113,044,178 | 194.3 kb | Distal (>10kb) Multiome | 105 | |
| chr1:113,072,181–113,073,766 | 223.3 kb | Distal (>10kb) Multiome | 975 | |
| chr1:113,140,616–113,141,422 | 291.2 kb | Distal (>10kb) Multiome | 413 |
Genomic view of the LINC01356 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.