Enables myosin II head/neck binding activity. Involved in several processes, including cytoplasmic actin-based contraction involved in cell motility; positive regulation of stress fiber assembly; and regulation of focal adhesion assembly. Located in myosin II complex and stress fiber. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for LIMCH1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LIMCH1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LIMCH1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:41,213,575–41,215,619 | 146.2 kb | Distal (>10kb) Multiome | 729 | |
| chr4:41,215,788–41,216,995 | 144.3 kb | Distal (>10kb) Multiome | 821 | |
| chr4:41,256,257–41,258,246 | 103.9 kb | Distal (>10kb) Multiome | 547 | |
| chr4:41,308,911–41,309,973 | 51.4 kb | Distal (>10kb) Multiome HiCAR | 89 | |
| chr4:41,359,120–41,359,380 | 1.2 kb | Proximal (<10kb) | 130 | |
| chr4:41,359,963–41,361,549 | 88 bp | At TSS Multiome HiCAR | 452 | |
| chr4:41,362,996–41,363,386 | 2.4 kb | Proximal (<10kb) | 122 | |
| chr4:41,608,681–41,609,185 | 3.7 kb | Proximal (<10kb) | 17 | |
| chr4:41,614,658–41,614,817 | 1.8 kb | Proximal (<10kb) | 17 | |
| chr4:41,619,123–41,619,519 | 6.2 kb | Proximal (<10kb) | 75 | |
| chr4:41,620,515–41,621,216 | 7.6 kb | Proximal (<10kb) | 81 | |
| chr4:41,644,230–41,644,895 | 283.7 kb | Distal (>10kb) Multiome HiCAR | 292 | |
| chr4:41,880,210–41,881,871 | 520.0 kb | Distal (>10kb) Multiome | 107 |
Genomic view of the LIMCH1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.