This module contains 14 genes including RELN, ITPR1, PCSK2, and ARB2A, with enrichment in secretory pathway, calcium signaling, and vesicular transport processes. Knockdown of FOXH1, SMAD4, and SOX17 represses this module, indicating these transcription factors are required for its expression during endoderm differentiation.
Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).
| TF | Dir | NES | #gRNA | padj | Bind | OR |
|---|
GO terms and pathway annotations enriched in this gene set (g:Profiler).
| Term | Source | p-value | Genes |
|---|
No significant enrichment terms.
All genes assigned to this co-expression submodule.
| Gene | Type | Publications |
|---|
Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.