This gene encodes a class 1 aminoacyl-tRNA synthetase, mitochondrial leucyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for LARS2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LARS2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LARS2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:45,145,719–45,146,718 | 242.3 kb | Distal (>10kb) Multiome | 356 | |
| chr3:45,224,890–45,226,655 | 163.4 kb | Distal (>10kb) Multiome HiCAR | 505 | |
| chr3:45,380,040–45,380,396 | 8.2 kb | Proximal (<10kb) | 6 | |
| chr3:45,388,133–45,389,048 | 96 bp | At TSS Multiome | 847 | |
| chr3:45,593,037–45,594,632 | 204.7 kb | Distal (>10kb) Multiome | 938 | |
| chr3:45,673,142–45,673,693 | 284.8 kb | Distal (>10kb) Multiome | 31 | |
| chr3:45,684,209–45,684,875 | 296.0 kb | Distal (>10kb) Multiome | 109 | |
| chr3:45,685,643–45,686,405 | 297.4 kb | Distal (>10kb) Multiome | 42 |
Genomic view of the LARS2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.