Transcription factors with Perturb-seq knockdown data for LARRPM. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LARRPM upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LARRPM, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:26,956,244–26,957,132 | 63.9 kb | Distal (>10kb) Multiome | 399 | |
| chr6:27,019,699–27,020,456 | 112 bp | At TSS Multiome | 707 | |
| chr6:27,020,685–27,021,156 | 405 bp | At TSS | 88 | |
| chr6:27,047,461–27,047,994 | 27.5 kb | Distal (>10kb) Multiome | 28 | |
| chr6:27,049,960–27,050,724 | 30.0 kb | Distal (>10kb) Multiome | 99 | |
| chr6:27,091,728–27,092,257 | 71.6 kb | Distal (>10kb) Multiome | 610 | |
| chr6:27,131,467–27,132,107 | 111.4 kb | Distal (>10kb) Multiome | 580 | |
| chr6:27,132,200–27,134,276 | 112.6 kb | Distal (>10kb) Multiome | 975 | |
| chr6:27,139,091–27,140,128 | 119.1 kb | Distal (>10kb) Multiome | 662 | |
| chr6:27,145,480–27,148,111 | 126.8 kb | Distal (>10kb) Multiome | 951 | |
| chr6:27,177,493–27,178,620 | 157.8 kb | Distal (>10kb) Multiome | 685 | |
| chr6:27,188,443–27,189,128 | 168.5 kb | Distal (>10kb) Multiome | 398 | |
| chr6:27,214,739–27,215,257 | 194.8 kb | Distal (>10kb) Multiome | 338 | |
| chr6:27,230,181–27,230,668 | 210.2 kb | Distal (>10kb) Multiome | 624 | |
| chr6:27,250,707–27,252,203 | 231.4 kb | Distal (>10kb) Multiome | 736 | |
| chr6:27,279,529–27,280,388 | 260.0 kb | Distal (>10kb) Multiome | 560 | |
| chr6:27,290,574–27,291,026 | 270.4 kb | Distal (>10kb) Multiome | 324 |
Genomic view of the LARRPM locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.