Contributes to guanyl-nucleotide exchange factor activity and molecular adaptor activity. Involved in several processes, including cellular response to amino acid stimulus; positive regulation of TORC1 signaling; and protein localization to lysosome. Located in lysosome. Part of FNIP-folliculin RagC/D GAP and Ragulator complex. Is active in lysosomal membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for LAMTOR4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LAMTOR4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LAMTOR4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:99,929,116–99,929,724 | 219.4 kb | Distal (>10kb) Multiome | 300 | |
| chr7:100,015,387–100,016,069 | 133.3 kb | Distal (>10kb) Multiome | 744 | |
| chr7:100,049,441–100,050,060 | 99.1 kb | Distal (>10kb) Multiome | 800 | |
| chr7:100,081,134–100,083,000 | 67.0 kb | Distal (>10kb) Multiome | 1160 | |
| chr7:100,088,454–100,089,460 | 59.9 kb | Distal (>10kb) Multiome | 955 | |
| chr7:100,100,270–100,102,380 | 48.3 kb | Distal (>10kb) Multiome | 1102 | |
| chr7:100,119,029–100,120,415 | 29.4 kb | Distal (>10kb) Multiome | 954 | |
| chr7:100,126,675–100,128,006 | 21.7 kb | Distal (>10kb) Multiome | 919 | |
| chr7:100,148,262–100,149,663 | 74 bp | At TSS Multiome | 846 | |
| chr7:100,158,247–100,159,079 | 9.9 kb | Proximal (<10kb) Multiome | 795 | |
| chr7:100,167,090–100,167,783 | 18.6 kb | Distal (>10kb) Multiome | 123 | |
| chr7:100,167,894–100,168,793 | 19.7 kb | Distal (>10kb) Multiome | 439 | |
| chr7:100,171,153–100,171,887 | 22.6 kb | Distal (>10kb) Multiome | 233 | |
| chr7:100,176,986–100,178,152 | 28.6 kb | Distal (>10kb) Multiome | 626 | |
| chr7:100,266,531–100,267,045 | 117.9 kb | Distal (>10kb) Multiome | 24 | |
| chr7:100,270,225–100,270,813 | 121.7 kb | Distal (>10kb) Multiome | 103 | |
| chr7:100,271,732–100,272,774 | 123.4 kb | Distal (>10kb) Multiome | 530 | |
| chr7:100,335,652–100,336,470 | 187.2 kb | Distal (>10kb) Multiome | 706 | |
| chr7:100,381,682–100,382,670 | 233.1 kb | Distal (>10kb) Multiome | 49 | |
| chr7:100,428,059–100,431,175 | 280.0 kb | Distal (>10kb) Multiome | 1296 | |
| chr7:100,435,379–100,436,927 | 287.6 kb | Distal (>10kb) Multiome | 931 |
Genomic view of the LAMTOR4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.