Predicted to enable nucleic acid binding activity. Predicted to be involved in DNA integration and regulation of DNA-templated transcription. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for KRBA2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KRBA2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KRBA2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:8,079,261–8,080,640 | 297.2 kb | Distal (>10kb) Multiome | 613 | |
| chr17:8,109,567–8,110,530 | 266.4 kb | Distal (>10kb) Multiome | 360 | |
| chr17:8,117,780–8,119,396 | 257.8 kb | Distal (>10kb) Multiome | 684 | |
| chr17:8,119,590–8,122,560 | 256.1 kb | Distal (>10kb) Multiome | 968 | |
| chr17:8,123,407–8,124,386 | 252.6 kb | Distal (>10kb) Multiome | 296 | |
| chr17:8,125,308–8,126,995 | 251.0 kb | Distal (>10kb) Multiome | 724 | |
| chr17:8,138,425–8,139,804 | 237.7 kb | Distal (>10kb) Multiome | 981 | |
| chr17:8,151,026–8,151,640 | 225.5 kb | Distal (>10kb) Multiome | 435 | |
| chr17:8,151,914–8,152,786 | 224.2 kb | Distal (>10kb) Multiome | 633 | |
| chr17:8,153,878–8,154,864 | 222.3 kb | Distal (>10kb) Multiome | 644 | |
| chr17:8,155,928–8,157,418 | 220.1 kb | Distal (>10kb) Multiome | 789 | |
| chr17:8,162,377–8,163,907 | 213.7 kb | Distal (>10kb) Multiome | 637 | |
| chr17:8,172,460–8,174,346 | 203.2 kb | Distal (>10kb) Multiome | 1196 | |
| chr17:8,175,900–8,176,943 | 200.3 kb | Distal (>10kb) Multiome | 601 | |
| chr17:8,185,937–8,188,084 | 189.0 kb | Distal (>10kb) Multiome | 1065 | |
| chr17:8,189,376–8,190,688 | 186.4 kb | Distal (>10kb) Multiome | 748 | |
| chr17:8,192,025–8,192,719 | 184.3 kb | Distal (>10kb) Multiome | 452 | |
| chr17:8,210,139–8,210,786 | 166.1 kb | Distal (>10kb) Multiome | 778 | |
| chr17:8,220,662–8,224,088 | 153.7 kb | Distal (>10kb) Multiome | 1171 | |
| chr17:8,226,529–8,227,280 | 149.9 kb | Distal (>10kb) Multiome | 565 | |
| chr17:8,247,519–8,249,589 | 127.4 kb | Distal (>10kb) Multiome | 914 | |
| chr17:8,288,100–8,289,230 | 87.9 kb | Distal (>10kb) Multiome | 751 | |
| chr17:8,295,073–8,296,021 | 81.2 kb | Distal (>10kb) Multiome | 739 | |
| chr17:8,310,033–8,310,555 | 66.4 kb | Distal (>10kb) Multiome | 98 | |
| chr17:8,313,329–8,313,824 | 63.1 kb | Distal (>10kb) Multiome | 30 | |
| chr17:8,376,215–8,376,918 | 15 bp | At TSS Multiome | 888 | |
| chr17:8,382,925–8,384,028 | 6.7 kb | Proximal (<10kb) Multiome | 981 | |
| chr17:8,435,307–8,436,885 | 59.2 kb | Distal (>10kb) Multiome | 847 | |
| chr17:8,584,054–8,584,700 | 207.7 kb | Distal (>10kb) Multiome | 18 | |
| chr17:8,629,690–8,631,825 | 254.4 kb | Distal (>10kb) Multiome | 878 |
Genomic view of the KRBA2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.