Enables several functions, including ATP hydrolysis activity; WW domain binding activity; and plus-end-directed microtubule motor activity. Involved in positive regulation of cell population proliferation and positive regulation of cytokinesis. Located in several cellular components, including microtubule cytoskeleton; midbody; and nuclear lumen. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for KIF20B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KIF20B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KIF20B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:89,414,203–89,415,651 | 286.8 kb | Distal (>10kb) Multiome | 735 | |
| chr10:89,533,952–89,534,872 | 167.3 kb | Distal (>10kb) Multiome | 254 | |
| chr10:89,535,099–89,536,715 | 165.9 kb | Distal (>10kb) Multiome | 338 | |
| chr10:89,643,675–89,646,137 | 57.5 kb | Distal (>10kb) Multiome | 1058 | |
| chr10:89,701,088–89,702,002 | 66 bp | At TSS Multiome | 944 | |
| chr10:89,702,102–89,702,301 | 513 bp | At TSS | 157 | |
| chr10:90,856,822–90,858,669 | 1156.3 kb | Distal (>10kb) Multiome HiCAR | 536 |
Genomic view of the KIF20B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.