KHSRP
KH-type splicing regulatory protein | FBP2, FUBP2, KSRP

The KHSRP gene encodes a multifunctional RNA-binding protein implicated in a variety of cellular processes, including transcription, alternative pre-mRNA splicing, and mRNA localization (Min et al., 1997 [PubMed 9136930]; Gherzi et al., 2004 [PubMed 15175153]).[supplied by OMIM, Apr 2010]

Member of: DE-11 DE-11.4
Biological processes 31 terms
3'-UTR-mediated mRNA destabilization (GO:0061158)3'-UTR-mediated mRNA destabilization (GO:0061158)RNA binding (GO:0003723)RNA binding (GO:0003723)RNA splicing (GO:0008380)RNA splicing, via transesterification reactions (GO:0000375)cellular response to cytokine stimulus (GO:0071345)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)exosome (RNase complex) (GO:0000178)mRNA 3'-UTR AU-rich region binding (GO:0035925)mRNA 3'-UTR binding (GO:0003730)mRNA binding (GO:0003729)mRNA processing (GO:0006397)membrane (GO:0016020)miRNA metabolic process (GO:0010586)negative regulation of low-density lipoprotein particle clearance (GO:0010989)negative regulation of nitric oxide biosynthetic process (GO:0045019)nucleic acid binding (GO:0003676)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of mRNA catabolic process (GO:0061014)protein binding (GO:0005515)protein folding (GO:0006457)protein folding chaperone (GO:0044183)regulation of DNA-templated transcription (GO:0006355)regulation of mRNA stability (GO:0043488)regulation of mRNA stability (GO:0043488)
Expression (TPM)
KHSRP — as a Regulated Gene

TFs regulating KHSRP 0 TFs

Transcription factors with Perturb-seq knockdown data for KHSRP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KHSRP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to KHSRP

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KHSRP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr19:6,199,134–6,200,121 225.1 kb Distal (>10kb) Multiome 769
chr19:6,279,539–6,280,376 144.7 kb Distal (>10kb) Multiome 761
chr19:6,361,350–6,362,018 63.2 kb Distal (>10kb) Multiome 803
chr19:6,372,272–6,374,427 51.4 kb Distal (>10kb) Multiome 925
chr19:6,392,902–6,394,077 31.3 kb Distal (>10kb) Multiome 767
chr19:6,423,613–6,425,899 356 bp At TSS Multiome 956
chr19:6,458,960–6,460,940 35.6 kb Distal (>10kb) Multiome 859
chr19:6,463,863–6,464,838 39.4 kb Distal (>10kb) Multiome 526
chr19:6,470,903–6,471,589 46.4 kb Distal (>10kb) Multiome 26
chr19:6,475,386–6,477,353 51.8 kb Distal (>10kb) Multiome 419
chr19:6,515,952–6,517,331 91.4 kb Distal (>10kb) Multiome 732
chr19:6,530,842–6,531,584 106.2 kb Distal (>10kb) Multiome 640
chr19:6,551,766–6,552,224 127.2 kb Distal (>10kb) Multiome 403
chr19:6,656,104–6,656,671 231.6 kb Distal (>10kb) Multiome 10
chr19:6,661,103–6,661,799 236.8 kb Distal (>10kb) Multiome 83
chr19:6,718,413–6,719,236 294.1 kb Distal (>10kb) Multiome 284

Genome Browser

Genomic view of the KHSRP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr19:6,189,134 – 6,729,236
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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