Enables ankyrin binding activity; cullin family protein binding activity; and identical protein binding activity. Involved in negative regulation of smoothened signaling pathway and ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for KCTD6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KCTD6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KCTD6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:58,217,189–58,217,783 | 274.7 kb | Distal (>10kb) Multiome | 545 | |
| chr3:58,222,267–58,222,780 | 269.6 kb | Distal (>10kb) Multiome | 115 | |
| chr3:58,236,918–58,238,686 | 254.5 kb | Distal (>10kb) Multiome | 727 | |
| chr3:58,305,855–58,306,746 | 185.8 kb | Distal (>10kb) Multiome | 875 | |
| chr3:58,332,558–58,333,709 | 159.2 kb | Distal (>10kb) Multiome | 705 | |
| chr3:58,433,383–58,434,404 | 58.2 kb | Distal (>10kb) Multiome | 938 | |
| chr3:58,434,510–58,435,588 | 56.9 kb | Distal (>10kb) Multiome | 226 | |
| chr3:58,441,570–58,442,309 | 50.1 kb | Distal (>10kb) Multiome | 65 | |
| chr3:58,450,170–58,450,919 | 41.5 kb | Distal (>10kb) Multiome | 20 | |
| chr3:58,463,546–58,463,974 | 28.3 kb | Distal (>10kb) Multiome | 479 | |
| chr3:58,470,966–58,471,873 | 20.6 kb | Distal (>10kb) Multiome | 742 | |
| chr3:58,491,060–58,492,581 | 159 bp | At TSS Multiome | 631 | |
| chr3:58,497,160–58,497,381 | 5.1 kb | Proximal (<10kb) | 68 | |
| chr3:58,585,026–58,585,766 | 93.4 kb | Distal (>10kb) Multiome | 401 | |
| chr3:58,586,723–58,587,275 | 94.9 kb | Distal (>10kb) Multiome | 131 | |
| chr3:58,629,982–58,630,563 | 138.2 kb | Distal (>10kb) Multiome | 197 | |
| chr3:58,640,649–58,641,138 | 148.7 kb | Distal (>10kb) Multiome | 288 |
Genomic view of the KCTD6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.