Enables identical protein binding activity and small GTPase binding activity. Contributes to ubiquitin-protein transferase activity. Involved in several processes, including negative regulation of Rho protein signal transduction; proteasome-mediated ubiquitin-dependent protein catabolic process; and stress fiber assembly. Located in nuclear body. Part of Cul3-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for KCTD13. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KCTD13 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KCTD13, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:29,666,524–29,667,045 | 259.5 kb | Distal (>10kb) Multiome | 338 | |
| chr16:29,678,867–29,679,831 | 247.0 kb | Distal (>10kb) Multiome | 783 | |
| chr16:29,708,839–29,709,431 | 217.1 kb | Distal (>10kb) Multiome | 96 | |
| chr16:29,709,743–29,710,091 | 216.2 kb | Distal (>10kb) Multiome | 21 | |
| chr16:29,784,957–29,785,426 | 141.0 kb | Distal (>10kb) Multiome | 452 | |
| chr16:29,790,073–29,791,192 | 135.6 kb | Distal (>10kb) Multiome | 1003 | |
| chr16:29,804,592–29,808,172 | 120.4 kb | Distal (>10kb) Multiome | 1275 | |
| chr16:29,810,746–29,812,649 | 113.8 kb | Distal (>10kb) Multiome | 826 | |
| chr16:29,815,828–29,817,186 | 110.1 kb | Distal (>10kb) Multiome | 1006 | |
| chr16:29,862,597–29,863,901 | 62.8 kb | Distal (>10kb) Multiome | 953 | |
| chr16:29,876,281–29,878,282 | 48.5 kb | Distal (>10kb) Multiome | 319 | |
| chr16:29,899,174–29,900,833 | 26.7 kb | Distal (>10kb) Multiome | 1019 | |
| chr16:29,925,692–29,926,784 | 26 bp | At TSS Multiome | 912 | |
| chr16:29,961,477–29,962,530 | 35.8 kb | Distal (>10kb) Multiome | 848 | |
| chr16:29,973,238–29,974,906 | 47.5 kb | Distal (>10kb) Multiome | 935 | |
| chr16:29,994,888–29,996,728 | 69.9 kb | Distal (>10kb) Multiome | 1080 | |
| chr16:30,021,215–30,021,860 | 95.3 kb | Distal (>10kb) Multiome | 764 | |
| chr16:30,052,803–30,053,364 | 126.9 kb | Distal (>10kb) Multiome | 989 | |
| chr16:30,063,722–30,066,296 | 137.9 kb | Distal (>10kb) Multiome | 1209 | |
| chr16:30,075,490–30,076,439 | 149.7 kb | Distal (>10kb) Multiome | 828 | |
| chr16:30,090,881–30,092,910 | 166.6 kb | Distal (>10kb) Multiome | 1101 | |
| chr16:30,095,557–30,096,839 | 170.1 kb | Distal (>10kb) Multiome | 824 | |
| chr16:30,122,728–30,123,578 | 197.0 kb | Distal (>10kb) Multiome | 718 | |
| chr16:30,182,759–30,183,865 | 257.2 kb | Distal (>10kb) Multiome | 547 |
Genomic view of the KCTD13 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.