This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for KCNK12. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KCNK12 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KCNK12, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:47,272,083–47,272,830 | 298.5 kb | Distal (>10kb) Multiome | 744 | |
| chr2:47,309,704–47,310,671 | 260.9 kb | Distal (>10kb) Multiome | 599 | |
| chr2:47,344,928–47,345,791 | 225.8 kb | Distal (>10kb) Multiome | 714 | |
| chr2:47,357,404–47,357,893 | 213.4 kb | Distal (>10kb) Multiome | 106 | |
| chr2:47,368,887–47,370,156 | 201.8 kb | Distal (>10kb) Multiome | 897 | |
| chr2:47,401,975–47,403,688 | 168.0 kb | Distal (>10kb) Multiome | 1037 | |
| chr2:47,569,846–47,572,135 | 210 bp | At TSS Multiome | 861 | |
| chr2:47,687,986–47,688,838 | 117.3 kb | Distal (>10kb) Multiome | 108 | |
| chr2:47,695,400–47,699,248 | 127.7 kb | Distal (>10kb) Multiome HiCAR | 441 | |
| chr2:47,727,846–47,728,468 | 157.2 kb | Distal (>10kb) Multiome | 46 | |
| chr2:47,755,307–47,756,515 | 185.0 kb | Distal (>10kb) Multiome HiCAR | 263 | |
| chr2:47,757,206–47,758,182 | 186.6 kb | Distal (>10kb) Multiome HiCAR | 88 | |
| chr2:47,759,506–47,760,474 | 189.0 kb | Distal (>10kb) Multiome HiCAR | 166 | |
| chr2:47,767,901–47,768,582 | 197.1 kb | Distal (>10kb) Multiome HiCAR | 421 | |
| chr2:47,782,231–47,784,581 | 213.1 kb | Distal (>10kb) Multiome | 1079 |
Genomic view of the KCNK12 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.