This gene encodes a cytoplasmic protein which contains SH3 domains. This protein is a member of a family of proteins involved in clathrin-mediated endocytosis. Intersectin 2 is thought to regulate the formation of clathrin-coated vesicles and also may function in the induction of T cell antigen receptor (TCR) endocytosis. [provided by RefSeq, Jan 2017]
Transcription factors with Perturb-seq knockdown data for ITSN2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ITSN2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ITSN2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:24,075,859–24,077,721 | 283.8 kb | Distal (>10kb) Multiome | 1100 | |
| chr2:24,083,513–24,085,355 | 276.1 kb | Distal (>10kb) Multiome | 1088 | |
| chr2:24,123,015–24,123,986 | 237.0 kb | Distal (>10kb) Multiome | 899 | |
| chr2:24,191,824–24,192,305 | 168.5 kb | Distal (>10kb) Multiome | 68 | |
| chr2:24,280,210–24,280,709 | 80.1 kb | Distal (>10kb) Multiome | 38 | |
| chr2:24,315,559–24,316,125 | 44.8 kb | Distal (>10kb) Multiome | 99 | |
| chr2:24,359,764–24,361,015 | 30 bp | At TSS Multiome | 909 | |
| chr2:24,456,964–24,457,548 | 96.7 kb | Distal (>10kb) Multiome | 112 | |
| chr2:24,489,608–24,492,569 | 130.5 kb | Distal (>10kb) Multiome | 854 |
Genomic view of the ITSN2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.