Predicted to enable oligosaccharide binding activity. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ITLN2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ITLN2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ITLN2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:160,658,117–160,659,135 | 296.3 kb | Distal (>10kb) Multiome | 111 | |
| chr1:160,665,307–160,666,295 | 289.1 kb | Distal (>10kb) Multiome | 417 | |
| chr1:160,674,985–160,675,879 | 279.2 kb | Distal (>10kb) Multiome HiCAR | 258 | |
| chr1:160,681,274–160,681,823 | 273.2 kb | Distal (>10kb) Multiome HiCAR | 237 | |
| chr1:160,726,492–160,727,108 | 228.0 kb | Distal (>10kb) Multiome HiCAR | 322 | |
| chr1:160,910,331–160,911,177 | 44.1 kb | Distal (>10kb) Multiome | 97 | |
| chr1:160,947,055–160,947,669 | 7.4 kb | Proximal (<10kb) Multiome | 35 | |
| chr1:160,948,057–160,948,424 | 6.4 kb | Proximal (<10kb) | 25 | |
| chr1:160,948,561–160,949,851 | 5.4 kb | Proximal (<10kb) Multiome | 173 | |
| chr1:160,951,273–160,951,853 | 3.0 kb | Proximal (<10kb) | 183 | |
| chr1:160,954,234–160,954,521 | 287 bp | At TSS | 144 | |
| chr1:160,954,772–160,954,947 | at TSS | At TSS | 31 | |
| chr1:160,981,323–160,982,552 | 27.0 kb | Distal (>10kb) Multiome | 156 | |
| chr1:161,020,536–161,021,920 | 66.4 kb | Distal (>10kb) Multiome | 846 | |
| chr1:161,038,489–161,039,130 | 84.1 kb | Distal (>10kb) Multiome | 468 | |
| chr1:161,045,080–161,046,516 | 91.2 kb | Distal (>10kb) Multiome | 927 | |
| chr1:161,097,691–161,099,047 | 143.5 kb | Distal (>10kb) Multiome | 829 | |
| chr1:161,117,504–161,118,419 | 163.3 kb | Distal (>10kb) Multiome | 794 | |
| chr1:161,131,760–161,133,351 | 177.9 kb | Distal (>10kb) Multiome | 956 | |
| chr1:161,153,700–161,154,461 | 199.2 kb | Distal (>10kb) Multiome | 816 | |
| chr1:161,158,928–161,160,167 | 204.7 kb | Distal (>10kb) Multiome | 706 | |
| chr1:161,165,740–161,167,170 | 211.5 kb | Distal (>10kb) Multiome | 888 | |
| chr1:161,176,874–161,177,972 | 222.7 kb | Distal (>10kb) Multiome | 910 | |
| chr1:161,198,215–161,199,209 | 243.7 kb | Distal (>10kb) Multiome | 357 | |
| chr1:161,201,572–161,202,783 | 247.5 kb | Distal (>10kb) Multiome | 852 | |
| chr1:161,225,326–161,226,910 | 271.1 kb | Distal (>10kb) Multiome | 710 | |
| chr1:161,227,235–161,227,802 | 272.7 kb | Distal (>10kb) Multiome | 372 |
Genomic view of the ITLN2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.