This gene encodes an inositol-3-phosphate synthase enzyme. The encoded protein plays a critical role in the myo-inositol biosynthesis pathway by catalyzing the rate-limiting conversion of glucose 6-phosphate to myoinositol 1-phosphate. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 4. [provided by RefSeq, Nov 2011]
Transcription factors with Perturb-seq knockdown data for ISYNA1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ISYNA1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ISYNA1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:18,152,230–18,153,823 | 285.3 kb | Distal (>10kb) Multiome | 809 | |
| chr19:18,160,950–18,161,791 | 276.7 kb | Distal (>10kb) Multiome | 494 | |
| chr19:18,173,513–18,174,441 | 264.4 kb | Distal (>10kb) Multiome | 667 | |
| chr19:18,192,530–18,193,908 | 245.1 kb | Distal (>10kb) Multiome | 758 | |
| chr19:18,202,796–18,205,452 | 233.9 kb | Distal (>10kb) Multiome | 823 | |
| chr19:18,220,660–18,221,487 | 217.1 kb | Distal (>10kb) Multiome | 134 | |
| chr19:18,223,665–18,226,306 | 214.1 kb | Distal (>10kb) Multiome | 790 | |
| chr19:18,232,737–18,233,413 | 205.0 kb | Distal (>10kb) Multiome | 789 | |
| chr19:18,278,462–18,282,788 | 156.3 kb | Distal (>10kb) Multiome | 1184 | |
| chr19:18,287,827–18,288,359 | 150.2 kb | Distal (>10kb) Multiome | 221 | |
| chr19:18,291,350–18,293,764 | 146.1 kb | Distal (>10kb) Multiome | 1026 | |
| chr19:18,322,635–18,323,493 | 114.9 kb | Distal (>10kb) Multiome | 814 | |
| chr19:18,328,417–18,328,936 | 109.5 kb | Distal (>10kb) Multiome | 488 | |
| chr19:18,339,807–18,340,160 | 98.2 kb | Distal (>10kb) Multiome | 249 | |
| chr19:18,340,428–18,341,393 | 97.6 kb | Distal (>10kb) Multiome | 747 | |
| chr19:18,373,917–18,374,961 | 63.6 kb | Distal (>10kb) Multiome | 971 | |
| chr19:18,388,239–18,388,884 | 49.6 kb | Distal (>10kb) Multiome | 910 | |
| chr19:18,416,224–18,418,189 | 21.5 kb | Distal (>10kb) Multiome | 893 | |
| chr19:18,418,296–18,420,432 | 18.7 kb | Distal (>10kb) Multiome | 773 | |
| chr19:18,428,554–18,429,777 | 9.0 kb | Proximal (<10kb) Multiome | 489 | |
| chr19:18,433,114–18,434,328 | 4.0 kb | Proximal (<10kb) Multiome | 446 | |
| chr19:18,436,634–18,439,166 | 878 bp | At TSS Multiome | 799 | |
| chr19:18,521,058–18,522,859 | 84.2 kb | Distal (>10kb) Multiome | 849 | |
| chr19:18,543,118–18,544,249 | 105.6 kb | Distal (>10kb) Multiome | 574 | |
| chr19:18,557,570–18,558,196 | 119.7 kb | Distal (>10kb) Multiome | 738 | |
| chr19:18,571,234–18,572,258 | 133.6 kb | Distal (>10kb) Multiome HiCAR | 972 | |
| chr19:18,588,272–18,591,023 | 152.5 kb | Distal (>10kb) Multiome | 1174 | |
| chr19:18,593,729–18,595,402 | 156.3 kb | Distal (>10kb) Multiome | 464 | |
| chr19:18,611,391–18,612,134 | 173.6 kb | Distal (>10kb) Multiome | 340 | |
| chr19:18,635,894–18,637,555 | 198.5 kb | Distal (>10kb) Multiome | 617 | |
| chr19:18,682,925–18,684,360 | 245.5 kb | Distal (>10kb) Multiome | 701 |
Genomic view of the ISYNA1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.