IQGAP3

IQ motif containing GTPase activating protein 3

Enables calmodulin binding activity and myosin VI light chain binding activity. Predicted to be involved in mitotic actomyosin contractile ring assembly actin filament organization. Predicted to act upstream of or within several processes, including G1/S transition of mitotic cell cycle; intracellular signaling cassette; and regulation of macromolecule metabolic process. Predicted to be located in cytosol. Predicted to be active in cell cortex. [provided by Alliance of Genome Resources, Apr 2025]

Member of: DE-11

Biological processes 14 terms

GTPase activator activity (GO:0005096)actin filament binding (GO:0051015)calmodulin binding (GO:0005516)calmodulin binding (GO:0005516)calmodulin binding (GO:0005516)cell cortex (GO:0005938)cell-cell junction (GO:0005911)cytoplasm (GO:0005737)cytosol (GO:0005829)lateral plasma membrane (GO:0016328)mitotic actomyosin contractile ring assembly actin filament organization (GO:1903479)myosin VI light chain binding (GO:0070856)protein binding (GO:0005515)small GTPase binding (GO:0031267)

Expression (TPM)

TFs regulating IQGAP3 0 TFs

Transcription factors with Perturb-seq knockdown data for IQGAP3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IQGAP3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to IQGAP3

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IQGAP3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr1:156,282,165–156,283,323	289.7 kb	Distal (>10kb) Multiome	973
chr1:156,291,233–156,291,857	281.0 kb	Distal (>10kb) Multiome	518
chr1:156,337,825–156,339,056	234.1 kb	Distal (>10kb) Multiome	836
chr1:156,356,873–156,357,393	215.5 kb	Distal (>10kb) Multiome	506
chr1:156,368,893–156,369,552	203.3 kb	Distal (>10kb) Multiome	529
chr1:156,420,712–156,422,291	150.8 kb	Distal (>10kb) Multiome	569
chr1:156,429,277–156,430,847	142.7 kb	Distal (>10kb) Multiome	231
chr1:156,432,112–156,432,986	139.9 kb	Distal (>10kb) Multiome	50
chr1:156,439,076–156,440,265	132.6 kb	Distal (>10kb) Multiome	264
chr1:156,456,348–156,457,982	115.8 kb	Distal (>10kb) Multiome	1033
chr1:156,499,927–156,501,599	71.6 kb	Distal (>10kb) Multiome	950
chr1:156,504,626–156,505,685	67.2 kb	Distal (>10kb) Multiome	911
chr1:156,572,298–156,572,749	4 bp	At TSS Multiome	580
chr1:156,583,883–156,584,356	11.5 kb	Distal (>10kb) Multiome	183
chr1:156,591,252–156,592,285	19.2 kb	Distal (>10kb) Multiome	706
chr1:156,601,188–156,601,796	28.9 kb	Distal (>10kb) Multiome	759
chr1:156,624,123–156,624,848	51.9 kb	Distal (>10kb) Multiome	472
chr1:156,641,772–156,642,623	69.5 kb	Distal (>10kb) Multiome	211
chr1:156,657,279–156,657,727	85.0 kb	Distal (>10kb) Multiome	357
chr1:156,659,788–156,660,816	87.6 kb	Distal (>10kb) Multiome	901
chr1:156,673,575–156,674,145	101.3 kb	Distal (>10kb) Multiome	269
chr1:156,676,488–156,677,779	104.8 kb	Distal (>10kb) Multiome	449
chr1:156,689,084–156,690,144	117.0 kb	Distal (>10kb) Multiome	508
chr1:156,692,653–156,693,825	120.6 kb	Distal (>10kb) Multiome	493
chr1:156,703,427–156,704,626	131.3 kb	Distal (>10kb) Multiome	182
chr1:156,704,839–156,707,238	133.6 kb	Distal (>10kb) Multiome	728
chr1:156,708,331–156,708,813	135.9 kb	Distal (>10kb) Multiome	108
chr1:156,728,152–156,729,282	156.1 kb	Distal (>10kb) Multiome	815
chr1:156,740,482–156,741,987	168.7 kb	Distal (>10kb) Multiome	1012
chr1:156,746,390–156,748,386	174.7 kb	Distal (>10kb) Multiome	750
chr1:156,751,012–156,752,594	179.3 kb	Distal (>10kb) Multiome	869
chr1:156,766,695–156,768,280	194.8 kb	Distal (>10kb) Multiome	967
chr1:156,813,606–156,814,470	241.5 kb	Distal (>10kb) Multiome	756
chr1:156,845,268–156,845,794	273.0 kb	Distal (>10kb) Multiome	73
chr1:156,848,614–156,849,138	276.4 kb	Distal (>10kb) Multiome	129
chr1:156,860,147–156,861,294	288.0 kb	Distal (>10kb) Multiome	484
chr1:156,862,753–156,863,585	290.7 kb	Distal (>10kb) Multiome	268

Genome Browser

Genomic view of the IQGAP3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.