IP6K2
inositol hexakisphosphate kinase 2 | IHPK2

This gene encodes a protein that belongs to the inositol phosphokinase (IPK) family. This protein is likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 and affect the growth suppressive and apoptotic activities of interferon-beta in some ovarian cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Member of: DE-2 DE-2.2
Biological processes 43 terms
cellular response to flavonoid (GO:1905396)cytoplasm (GO:0005737)diphosphoinositol pentakisphosphate kinase activity (GO:0000829)diphosphoinositol pentakisphosphate kinase activity (GO:0000829)diphosphoinositol tetrakisphosphate kinase activity (GO:0052839)diphosphoinositol tetrakisphosphate kinase activity (GO:0052839)fibrillar center (GO:0001650)flavonoid binding (GO:0097243)inositol 5-diphosphate pentakisphosphate 5-kinase activity (GO:0052836)inositol 5-diphosphate pentakisphosphate 5-kinase activity (GO:0052836)inositol hexakisphosphate 5-kinase activity (GO:0000832)inositol hexakisphosphate 5-kinase activity (GO:0000832)inositol hexakisphosphate kinase activity (GO:0000828)inositol hexakisphosphate kinase activity (GO:0000828)inositol hexakisphosphate kinase activity (GO:0000828)inositol hexakisphosphate kinase activity (GO:0000828)inositol phosphate biosynthetic process (GO:0032958)inositol phosphate biosynthetic process (GO:0032958)inositol phosphate metabolic process (GO:0043647)inositol phosphate metabolic process (GO:0043647)inositol phosphate metabolic process (GO:0043647)inositol-1,3,4,5,6-pentakisphosphate kinase activity (GO:0000827)inositol-1,3,4,5,6-pentakisphosphate kinase activity (GO:0000827)kinase activity (GO:0016301)negative regulation of cell growth (GO:0030308)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)organophosphate biosynthetic process (GO:0090407)phosphatidylinositol metabolic process (GO:0046488)phosphatidylinositol phosphate biosynthetic process (GO:0046854)phosphatidylinositol phosphate biosynthetic process (GO:0046854)positive regulation of apoptotic process (GO:0043065)positive regulation of peptidyl-serine phosphorylation (GO:0033138)positive regulation of peptidyl-serine phosphorylation (GO:0033138)positive regulation of protein K48-linked ubiquitination (GO:1902524)positive regulation of protein serine/threonine kinase activity (GO:0071902)protein binding (GO:0005515)protein stabilization (GO:0050821)protein stabilization (GO:0050821)protein-containing complex binding (GO:0044877)
Expression (TPM)
IP6K2 — as a Regulated Gene

TFs regulating IP6K2 0 TFs

Transcription factors with Perturb-seq knockdown data for IP6K2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IP6K2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to IP6K2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IP6K2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr3:48,428,528–48,430,504 287.2 kb Distal (>10kb) Multiome 910
chr3:48,439,801–48,440,548 277.0 kb Distal (>10kb) Multiome 787
chr3:48,446,396–48,447,180 270.5 kb Distal (>10kb) Multiome 767
chr3:48,465,344–48,466,310 251.5 kb Distal (>10kb) Multiome 670
chr3:48,472,636–48,473,658 244.0 kb Distal (>10kb) Multiome 821
chr3:48,503,451–48,504,839 213.1 kb Distal (>10kb) Multiome 419
chr3:48,556,022–48,557,666 160.2 kb Distal (>10kb) Multiome 794
chr3:48,558,131–48,558,793 158.8 kb Distal (>10kb) Multiome 503
chr3:48,608,816–48,610,628 107.6 kb Distal (>10kb) Multiome 850
chr3:48,634,696–48,636,251 81.6 kb Distal (>10kb) Multiome 898
chr3:48,655,787–48,657,257 60.8 kb Distal (>10kb) Multiome 438
chr3:48,661,275–48,664,636 55.5 kb Distal (>10kb) Multiome 1248
chr3:48,685,362–48,686,531 31.3 kb Distal (>10kb) Multiome 770
chr3:48,716,958–48,717,863 94 bp At TSS Multiome 634
chr3:48,847,059–48,848,224 130.6 kb Distal (>10kb) Multiome 772
chr3:48,898,423–48,899,110 181.7 kb Distal (>10kb) Multiome 739
chr3:48,918,234–48,919,609 201.6 kb Distal (>10kb) Multiome 877
chr3:48,989,537–48,991,069 272.8 kb Distal (>10kb) Multiome 552
chr3:49,003,975–49,004,995 287.3 kb Distal (>10kb) Multiome 209
chr3:49,006,738–49,008,496 290.7 kb Distal (>10kb) Multiome 955

Genome Browser

Genomic view of the IP6K2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr3:48,418,528 – 49,018,496
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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