The protein encoded by this gene can form a complex with human single-strand DNA binding proteins 1 or 2 (hSSB1 and hSSB2) and other proteins to mediate genome stability and the DNA damage response. The encoded protein is also part of a multiprotein complex that interacts with the C-terminal domain of RNA polymerase II large subunit to help regulate processing of U1 and U2 small nuclear RNAs. [provided by RefSeq, May 2016]
Transcription factors with Perturb-seq knockdown data for INTS3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = INTS3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of INTS3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:153,494,904–153,495,543 | 233.0 kb | Distal (>10kb) Multiome | 290 | |
| chr1:153,532,833–153,533,594 | 194.9 kb | Distal (>10kb) Multiome | 493 | |
| chr1:153,538,198–153,538,657 | 189.6 kb | Distal (>10kb) Multiome | 338 | |
| chr1:153,544,844–153,545,543 | 182.9 kb | Distal (>10kb) Multiome | 575 | |
| chr1:153,568,278–153,569,058 | 159.4 kb | Distal (>10kb) Multiome | 641 | |
| chr1:153,612,574–153,613,563 | 115.0 kb | Distal (>10kb) Multiome | 388 | |
| chr1:153,626,535–153,627,974 | 100.5 kb | Distal (>10kb) Multiome | 697 | |
| chr1:153,633,575–153,634,639 | 94.0 kb | Distal (>10kb) Multiome | 998 | |
| chr1:153,658,331–153,659,230 | 69.3 kb | Distal (>10kb) Multiome | 746 | |
| chr1:153,670,709–153,671,992 | 56.9 kb | Distal (>10kb) Multiome | 884 | |
| chr1:153,697,776–153,698,654 | 29.7 kb | Distal (>10kb) Multiome | 313 | |
| chr1:153,727,492–153,728,827 | 188 bp | At TSS Multiome | 702 | |
| chr1:153,736,782–153,737,426 | 9.0 kb | Proximal (<10kb) Multiome | 10 | |
| chr1:153,745,487–153,745,959 | 17.6 kb | Distal (>10kb) Multiome | 55 | |
| chr1:153,774,962–153,776,698 | 47.1 kb | Distal (>10kb) Multiome | 671 | |
| chr1:153,783,341–153,784,300 | 55.6 kb | Distal (>10kb) Multiome | 794 | |
| chr1:153,922,213–153,923,779 | 195.0 kb | Distal (>10kb) Multiome | 856 | |
| chr1:153,945,717–153,947,118 | 218.6 kb | Distal (>10kb) Multiome | 866 | |
| chr1:153,957,828–153,959,103 | 230.6 kb | Distal (>10kb) Multiome | 912 | |
| chr1:153,963,107–153,964,407 | 235.6 kb | Distal (>10kb) Multiome | 798 | |
| chr1:153,967,147–153,968,324 | 239.6 kb | Distal (>10kb) Multiome | 986 | |
| chr1:153,977,057–153,978,034 | 249.5 kb | Distal (>10kb) Multiome | 853 | |
| chr1:153,985,902–153,987,184 | 258.4 kb | Distal (>10kb) Multiome | 572 | |
| chr1:153,990,402–153,991,082 | 262.7 kb | Distal (>10kb) Multiome | 950 |
Genomic view of the INTS3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.