This gene is an immediate early gene that encodes a protein related to interferon-gamma. This protein may function as a transcriptional co-activator/repressor that controls the growth and differentiation of specific cell types during embryonic development and tissue regeneration. Mutations in this gene are associated with sensory/motor neuropathy with ataxia. This gene may also be involved in modulating the pathogenesis of cystic fibrosis lung disease. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2010]
Transcription factors with Perturb-seq knockdown data for IFRD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IFRD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IFRD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:112,161,873–112,162,630 | 288.2 kb | Distal (>10kb) Multiome | 400 | |
| chr7:112,205,004–112,207,424 | 243.9 kb | Distal (>10kb) Multiome | 937 | |
| chr7:112,249,400–112,250,828 | 200.2 kb | Distal (>10kb) Multiome | 130 | |
| chr7:112,421,817–112,422,507 | 635 bp | At TSS | 285 | |
| chr7:112,422,776–112,423,321 | at TSS | At TSS | 557 | |
| chr7:112,427,876–112,428,687 | 4.7 kb | Proximal (<10kb) | 61 | |
| chr7:112,449,726–112,451,867 | 72 bp | At TSS Multiome | 1086 | |
| chr7:112,452,139–112,452,751 | 1.7 kb | Proximal (<10kb) | 249 |
Genomic view of the IFRD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.