IER3

immediate early response 3 | DIF-2, IEX-1, IEX-1L, PRG1

This gene functions in the protection of cells from Fas- or tumor necrosis factor type alpha-induced apoptosis. Partially degraded and unspliced transcripts are found after virus infection in vitro, but these transcripts are not found in vivo and do not generate a valid protein. [provided by RefSeq, Jul 2008]

Member of: DE-4 DE-4.1 Developmental clusters: GC2

Biological processes 12 terms

DNA damage response (GO:0006974)DNA damage response (GO:0006974)anatomical structure morphogenesis (GO:0009653)apoptotic process (GO:0006915)cytosol (GO:0005829)membrane (GO:0016020)negative regulation of apoptotic process (GO:0043066)negative regulation of apoptotic process (GO:0043066)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)protein binding (GO:0005515)

Expression (TPM)

TFs regulating IER3 0 TFs

Transcription factors with Perturb-seq knockdown data for IER3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IER3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to IER3

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IER3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr6:30,466,230–30,466,713	278.0 kb	Distal (>10kb) Multiome	369
chr6:30,489,117–30,490,512	254.2 kb	Distal (>10kb) Multiome	750
chr6:30,516,006–30,516,707	228.2 kb	Distal (>10kb) Multiome	739
chr6:30,555,407–30,557,765	187.9 kb	Distal (>10kb) Multiome	1161
chr6:30,570,822–30,571,949	173.1 kb	Distal (>10kb) Multiome	1000
chr6:30,614,393–30,615,939	129.3 kb	Distal (>10kb) Multiome	837
chr6:30,616,770–30,618,155	127.0 kb	Distal (>10kb) Multiome	1072
chr6:30,626,560–30,627,206	117.7 kb	Distal (>10kb) Multiome	802
chr6:30,646,505–30,648,035	97.2 kb	Distal (>10kb) Multiome	961
chr6:30,672,571–30,673,266	71.6 kb	Distal (>10kb) Multiome	812
chr6:30,679,032–30,679,479	65.4 kb	Distal (>10kb) Multiome	603
chr6:30,686,268–30,688,032	57.3 kb	Distal (>10kb) Multiome	801
chr6:30,690,445–30,691,240	53.6 kb	Distal (>10kb) Multiome	644
chr6:30,716,986–30,717,874	27.1 kb	Distal (>10kb) Multiome	1059
chr6:30,719,428–30,720,577	24.4 kb	Distal (>10kb) Multiome	724
chr6:30,721,307–30,722,103	23.0 kb	Distal (>10kb) Multiome	872
chr6:30,725,731–30,726,564	18.3 kb	Distal (>10kb) Multiome	478
chr6:30,740,996–30,745,094	1.8 kb	Proximal (<10kb) Multiome	1233
chr6:30,763,647–30,765,193	19.9 kb	Distal (>10kb) Multiome	850
chr6:30,880,638–30,881,295	136.4 kb	Distal (>10kb) Multiome	124
chr6:30,882,560–30,883,422	138.3 kb	Distal (>10kb) Multiome	308
chr6:30,883,625–30,885,122	139.8 kb	Distal (>10kb) Multiome	538
chr6:30,907,770–30,908,494	163.6 kb	Distal (>10kb) Multiome	1005
chr6:30,913,674–30,914,800	169.7 kb	Distal (>10kb) Multiome	944
chr6:30,942,475–30,943,087	198.3 kb	Distal (>10kb) Multiome	300
chr6:30,955,192–30,955,975	211.2 kb	Distal (>10kb) Multiome	524

Genome Browser

Genomic view of the IER3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.