The protein encoded by this gene belongs to the inhibitor of DNA binding family, members of which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the inhibitor of DNA binding family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by suppressing their heterodimerization partners through the HLH domains. This protein may play a role in negatively regulating cell differentiation. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq, Aug 2011]
Transcription factors with Perturb-seq knockdown data for ID2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ID2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ID2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:7,430,339–7,431,763 | 1247.6 kb | Distal (>10kb) Multiome HiCAR | 376 | |
| chr2:7,703,564–7,704,214 | 975.1 kb | Distal (>10kb) Multiome HiCAR | 105 | |
| chr2:7,878,298–7,879,681 | 799.7 kb | Distal (>10kb) Multiome HiCAR | 217 | |
| chr2:8,582,837–8,584,915 | 94.9 kb | Distal (>10kb) Multiome | 618 | |
| chr2:8,676,120–8,676,376 | 2.5 kb | Proximal (<10kb) | 82 | |
| chr2:8,676,483–8,677,573 | 1.3 kb | Proximal (<10kb) | 319 | |
| chr2:8,677,675–8,679,558 | 89 bp | At TSS Multiome | 902 | |
| chr2:8,680,181–8,680,695 | 1.3 kb | Proximal (<10kb) | 599 | |
| chr2:8,680,827–8,683,692 | 3.1 kb | Proximal (<10kb) Multiome | 1154 | |
| chr2:8,684,500–8,686,247 | 7.0 kb | Proximal (<10kb) Multiome | 951 | |
| chr2:8,836,956–8,838,243 | 158.8 kb | Distal (>10kb) Multiome | 738 | |
| chr2:8,896,416–8,897,439 | 218.0 kb | Distal (>10kb) Multiome | 153 |
Genomic view of the ID2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.