The protein encoded by this gene may play a part in the beta-catenin/Lef signaling pathway. Expression of this gene is down-regulated by beta-catenin. Defects in this gene are a cause of hypomyelination with congenital cataract (HCC). [provided by RefSeq, Oct 2008]
Transcription factors with Perturb-seq knockdown data for HYCC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HYCC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HYCC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:22,782,701–22,783,430 | 231.0 kb | Distal (>10kb) Multiome | 163 | |
| chr7:22,822,496–22,823,057 | 191.2 kb | Distal (>10kb) Multiome | 671 | |
| chr7:22,853,488–22,855,243 | 159.8 kb | Distal (>10kb) Multiome | 941 | |
| chr7:22,937,587–22,938,683 | 75.9 kb | Distal (>10kb) Multiome | 139 | |
| chr7:23,011,552–23,011,857 | 2.2 kb | Proximal (<10kb) | 38 | |
| chr7:23,012,886–23,013,069 | 1.0 kb | Proximal (<10kb) | 150 | |
| chr7:23,013,184–23,014,464 | 106 bp | At TSS Multiome | 751 | |
| chr7:23,105,409–23,106,715 | 91.7 kb | Distal (>10kb) Multiome | 833 | |
| chr7:23,116,020–23,116,472 | 102.0 kb | Distal (>10kb) Multiome | 105 | |
| chr7:23,181,578–23,182,460 | 167.9 kb | Distal (>10kb) Multiome | 935 | |
| chr7:23,205,915–23,206,590 | 192.2 kb | Distal (>10kb) Multiome | 154 | |
| chr7:23,247,362–23,248,065 | 233.7 kb | Distal (>10kb) Multiome | 202 | |
| chr7:23,299,105–23,299,994 | 285.2 kb | Distal (>10kb) Multiome | 852 |
Genomic view of the HYCC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.