17-beta-hydroxysteroid dehydrogenases, such as HSD17B14, are primarily involved in metabolism of steroids at the C17 position and also of other substrates, such as fatty acids, prostaglandins, and xenobiotics (Lukacik et al., 2007 [PubMed 17067289]).[supplied by OMIM, Jun 2009]
Transcription factors with Perturb-seq knockdown data for HSD17B14. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HSD17B14 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HSD17B14, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:48,614,318–48,615,255 | 221.6 kb | Distal (>10kb) Multiome | 524 | |
| chr19:48,618,726–48,619,869 | 217.2 kb | Distal (>10kb) Multiome | 1012 | |
| chr19:48,623,839–48,624,688 | 212.3 kb | Distal (>10kb) Multiome | 529 | |
| chr19:48,629,369–48,631,306 | 206.5 kb | Distal (>10kb) Multiome | 402 | |
| chr19:48,634,242–48,636,244 | 200.8 kb | Distal (>10kb) Multiome | 868 | |
| chr19:48,636,802–48,639,603 | 198.1 kb | Distal (>10kb) Multiome | 956 | |
| chr19:48,645,454–48,647,163 | 189.9 kb | Distal (>10kb) Multiome | 750 | |
| chr19:48,675,421–48,675,873 | 160.9 kb | Distal (>10kb) Multiome | 415 | |
| chr19:48,695,830–48,697,033 | 140.4 kb | Distal (>10kb) Multiome | 253 | |
| chr19:48,713,646–48,714,846 | 122.2 kb | Distal (>10kb) Multiome | 719 | |
| chr19:48,716,551–48,717,038 | 119.6 kb | Distal (>10kb) Multiome | 241 | |
| chr19:48,720,420–48,721,301 | 115.6 kb | Distal (>10kb) Multiome | 689 | |
| chr19:48,735,001–48,735,602 | 101.3 kb | Distal (>10kb) Multiome | 161 | |
| chr19:48,738,441–48,739,812 | 97.6 kb | Distal (>10kb) Multiome | 743 | |
| chr19:48,741,194–48,741,939 | 95.0 kb | Distal (>10kb) Multiome | 350 | |
| chr19:48,746,830–48,747,395 | 89.4 kb | Distal (>10kb) Multiome | 402 | |
| chr19:48,752,314–48,753,547 | 83.6 kb | Distal (>10kb) Multiome | 545 | |
| chr19:48,795,165–48,795,736 | 41.0 kb | Distal (>10kb) Multiome | 724 | |
| chr19:48,806,734–48,807,478 | 29.6 kb | Distal (>10kb) Multiome | 452 | |
| chr19:48,810,774–48,811,494 | 25.5 kb | Distal (>10kb) Multiome | 662 | |
| chr19:48,812,048–48,813,099 | 24.0 kb | Distal (>10kb) Multiome | 603 | |
| chr19:48,829,998–48,830,690 | 6.2 kb | Proximal (<10kb) Multiome | 55 | |
| chr19:48,835,571–48,838,073 | 696 bp | At TSS Multiome | 621 | |
| chr19:48,872,000–48,873,835 | 35.9 kb | Distal (>10kb) Multiome | 987 | |
| chr19:48,895,958–48,896,628 | 59.8 kb | Distal (>10kb) Multiome | 207 | |
| chr19:48,899,782–48,900,620 | 63.7 kb | Distal (>10kb) Multiome | 710 | |
| chr19:48,933,397–48,933,948 | 97.1 kb | Distal (>10kb) Multiome | 458 | |
| chr19:48,954,440–48,955,356 | 118.3 kb | Distal (>10kb) Multiome | 905 | |
| chr19:48,963,322–48,964,187 | 127.3 kb | Distal (>10kb) Multiome | 866 | |
| chr19:48,964,515–48,966,446 | 128.7 kb | Distal (>10kb) Multiome | 1015 | |
| chr19:48,992,571–48,994,129 | 157.0 kb | Distal (>10kb) Multiome | 852 | |
| chr19:49,017,642–49,018,292 | 181.4 kb | Distal (>10kb) Multiome | 480 | |
| chr19:49,019,277–49,019,889 | 183.1 kb | Distal (>10kb) Multiome | 233 | |
| chr19:49,055,975–49,056,714 | 219.7 kb | Distal (>10kb) Multiome | 431 | |
| chr19:49,064,668–49,065,682 | 228.6 kb | Distal (>10kb) Multiome | 226 | |
| chr19:49,071,761–49,072,903 | 235.5 kb | Distal (>10kb) Multiome | 278 | |
| chr19:49,084,646–49,086,115 | 248.8 kb | Distal (>10kb) Multiome | 1030 | |
| chr19:49,113,727–49,115,240 | 278.5 kb | Distal (>10kb) Multiome | 746 | |
| chr19:49,118,477–49,120,300 | 282.6 kb | Distal (>10kb) Multiome | 949 | |
| chr19:49,127,647–49,128,949 | 291.7 kb | Distal (>10kb) Multiome | 1000 | |
| chr19:49,129,106–49,129,678 | 293.1 kb | Distal (>10kb) Multiome | 197 | |
| chr19:49,132,975–49,134,197 | 297.0 kb | Distal (>10kb) Multiome | 179 |
Genomic view of the HSD17B14 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.