HSD17B14
hydroxysteroid 17-beta dehydrogenase 14 | SDR47C1, retSDR3, DHRS10

17-beta-hydroxysteroid dehydrogenases, such as HSD17B14, are primarily involved in metabolism of steroids at the C17 position and also of other substrates, such as fatty acids, prostaglandins, and xenobiotics (Lukacik et al., 2007 [PubMed 17067289]).[supplied by OMIM, Jun 2009]

Member of: DE-4 Developmental clusters: GC7
Biological processes 10 terms
Expression (TPM)
HSD17B14 — as a Regulated Gene

TFs regulating HSD17B14 0 TFs

Transcription factors with Perturb-seq knockdown data for HSD17B14. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HSD17B14 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to HSD17B14

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HSD17B14, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr19:48,614,318–48,615,255 221.6 kb Distal (>10kb) Multiome 524
chr19:48,618,726–48,619,869 217.2 kb Distal (>10kb) Multiome 1012
chr19:48,623,839–48,624,688 212.3 kb Distal (>10kb) Multiome 529
chr19:48,629,369–48,631,306 206.5 kb Distal (>10kb) Multiome 402
chr19:48,634,242–48,636,244 200.8 kb Distal (>10kb) Multiome 868
chr19:48,636,802–48,639,603 198.1 kb Distal (>10kb) Multiome 956
chr19:48,645,454–48,647,163 189.9 kb Distal (>10kb) Multiome 750
chr19:48,675,421–48,675,873 160.9 kb Distal (>10kb) Multiome 415
chr19:48,695,830–48,697,033 140.4 kb Distal (>10kb) Multiome 253
chr19:48,713,646–48,714,846 122.2 kb Distal (>10kb) Multiome 719
chr19:48,716,551–48,717,038 119.6 kb Distal (>10kb) Multiome 241
chr19:48,720,420–48,721,301 115.6 kb Distal (>10kb) Multiome 689
chr19:48,735,001–48,735,602 101.3 kb Distal (>10kb) Multiome 161
chr19:48,738,441–48,739,812 97.6 kb Distal (>10kb) Multiome 743
chr19:48,741,194–48,741,939 95.0 kb Distal (>10kb) Multiome 350
chr19:48,746,830–48,747,395 89.4 kb Distal (>10kb) Multiome 402
chr19:48,752,314–48,753,547 83.6 kb Distal (>10kb) Multiome 545
chr19:48,795,165–48,795,736 41.0 kb Distal (>10kb) Multiome 724
chr19:48,806,734–48,807,478 29.6 kb Distal (>10kb) Multiome 452
chr19:48,810,774–48,811,494 25.5 kb Distal (>10kb) Multiome 662
chr19:48,812,048–48,813,099 24.0 kb Distal (>10kb) Multiome 603
chr19:48,829,998–48,830,690 6.2 kb Proximal (<10kb) Multiome 55
chr19:48,835,571–48,838,073 696 bp At TSS Multiome 621
chr19:48,872,000–48,873,835 35.9 kb Distal (>10kb) Multiome 987
chr19:48,895,958–48,896,628 59.8 kb Distal (>10kb) Multiome 207
chr19:48,899,782–48,900,620 63.7 kb Distal (>10kb) Multiome 710
chr19:48,933,397–48,933,948 97.1 kb Distal (>10kb) Multiome 458
chr19:48,954,440–48,955,356 118.3 kb Distal (>10kb) Multiome 905
chr19:48,963,322–48,964,187 127.3 kb Distal (>10kb) Multiome 866
chr19:48,964,515–48,966,446 128.7 kb Distal (>10kb) Multiome 1015
chr19:48,992,571–48,994,129 157.0 kb Distal (>10kb) Multiome 852
chr19:49,017,642–49,018,292 181.4 kb Distal (>10kb) Multiome 480
chr19:49,019,277–49,019,889 183.1 kb Distal (>10kb) Multiome 233
chr19:49,055,975–49,056,714 219.7 kb Distal (>10kb) Multiome 431
chr19:49,064,668–49,065,682 228.6 kb Distal (>10kb) Multiome 226
chr19:49,071,761–49,072,903 235.5 kb Distal (>10kb) Multiome 278
chr19:49,084,646–49,086,115 248.8 kb Distal (>10kb) Multiome 1030
chr19:49,113,727–49,115,240 278.5 kb Distal (>10kb) Multiome 746
chr19:49,118,477–49,120,300 282.6 kb Distal (>10kb) Multiome 949
chr19:49,127,647–49,128,949 291.7 kb Distal (>10kb) Multiome 1000
chr19:49,129,106–49,129,678 293.1 kb Distal (>10kb) Multiome 197
chr19:49,132,975–49,134,197 297.0 kb Distal (>10kb) Multiome 179

Genome Browser

Genomic view of the HSD17B14 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr19:48,604,318 – 49,144,197
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq