Enables RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Located in nucleus. Part of catalytic step 2 spliceosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for HNRNPA3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HNRNPA3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HNRNPA3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:176,122,221–176,123,570 | 1089.9 kb | Distal (>10kb) Multiome HiCAR | 242 | |
| chr2:177,024,602–177,025,177 | 187.8 kb | Distal (>10kb) Multiome | 113 | |
| chr2:177,204,472–177,204,729 | 8.1 kb | Proximal (<10kb) | 34 | |
| chr2:177,211,967–177,213,482 | 148 bp | At TSS Multiome | 1144 | |
| chr2:177,263,465–177,265,584 | 52.1 kb | Distal (>10kb) Multiome | 1275 | |
| chr2:177,284,272–177,285,351 | 71.9 kb | Distal (>10kb) Multiome | 132 | |
| chr2:177,310,707–177,311,501 | 98.3 kb | Distal (>10kb) Multiome | 84 | |
| chr2:177,392,346–177,393,257 | 180.0 kb | Distal (>10kb) Multiome | 1012 | |
| chr2:177,478,776–177,479,348 | 266.3 kb | Distal (>10kb) Multiome | 41 |
Genomic view of the HNRNPA3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.