Predicted to enable guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for HDDC3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HDDC3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HDDC3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:90,716,853–90,717,827 | 215.3 kb | Distal (>10kb) Multiome | 824 | |
| chr15:90,839,491–90,840,162 | 92.8 kb | Distal (>10kb) Multiome | 261 | |
| chr15:90,883,883–90,884,953 | 48.1 kb | Distal (>10kb) Multiome | 304 | |
| chr15:90,902,271–90,903,624 | 29.9 kb | Distal (>10kb) Multiome | 817 | |
| chr15:90,931,729–90,933,077 | 607 bp | At TSS Multiome | 926 | |
| chr15:90,934,164–90,935,936 | 2.7 kb | Proximal (<10kb) Multiome | 701 | |
| chr15:90,954,493–90,955,641 | 22.4 kb | Distal (>10kb) Multiome | 974 | |
| chr15:90,956,070–90,957,754 | 24.2 kb | Distal (>10kb) Multiome | 410 | |
| chr15:90,994,023–90,995,142 | 62.2 kb | Distal (>10kb) Multiome | 929 | |
| chr15:91,021,873–91,022,829 | 90.0 kb | Distal (>10kb) Multiome | 735 | |
| chr15:91,032,872–91,033,463 | 100.7 kb | Distal (>10kb) Multiome | 347 | |
| chr15:91,099,400–91,100,613 | 167.6 kb | Distal (>10kb) Multiome | 351 | |
| chr15:91,101,202–91,101,847 | 169.0 kb | Distal (>10kb) Multiome | 48 | |
| chr15:91,140,477–91,140,966 | 208.2 kb | Distal (>10kb) Multiome | 31 | |
| chr15:91,202,218–91,202,996 | 270.2 kb | Distal (>10kb) Multiome | 29 | |
| chr15:92,647,486–92,648,715 | 1715.4 kb | Distal (>10kb) Multiome HiCAR | 186 |
Genomic view of the HDDC3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.