The protein encoded by this gene can catalyze the third step (dehydration) in the conversion of long chain fatty acids to very long chain fatty acids. The encoded protein localizes to the endoplasmic reticulum membrane. [provided by RefSeq, Jul 2016]
Transcription factors with Perturb-seq knockdown data for HACD2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HACD2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HACD2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:123,314,223–123,315,571 | 270.0 kb | Distal (>10kb) Multiome | 264 | |
| chr3:123,447,574–123,450,476 | 137.0 kb | Distal (>10kb) Multiome | 427 | |
| chr3:123,571,319–123,571,775 | 13.5 kb | Distal (>10kb) Multiome | 101 | |
| chr3:123,584,314–123,585,841 | 122 bp | At TSS Multiome | 988 | |
| chr3:123,586,059–123,586,522 | 1.0 kb | Proximal (<10kb) | 281 | |
| chr3:123,588,179–123,588,401 | 3.1 kb | Proximal (<10kb) | 11 | |
| chr3:123,600,718–123,601,402 | 16.0 kb | Distal (>10kb) Multiome | 74 | |
| chr3:123,636,347–123,636,942 | 51.6 kb | Distal (>10kb) Multiome | 211 | |
| chr3:123,883,672–123,884,952 | 299.4 kb | Distal (>10kb) Multiome | 407 |
Genomic view of the HACD2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.