This gene is an estrogen-responsive gene that is an early response gene in the estrogen receptor-regulated pathway. It is thought to play an important role in hormone-responsive tissues and cancer. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for GREB1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GREB1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GREB1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:11,343,518–11,345,475 | 137.6 kb | Distal (>10kb) Multiome | 1010 | |
| chr2:11,465,452–11,466,561 | 16.2 kb | Distal (>10kb) Multiome | 1149 | |
| chr2:11,478,007–11,478,397 | 3.9 kb | Proximal (<10kb) | 305 | |
| chr2:11,481,838–11,483,838 | 460 bp | At TSS Multiome | 777 | |
| chr2:11,533,291–11,533,525 | 9.2 kb | Proximal (<10kb) | 317 | |
| chr2:11,539,056–11,540,222 | 57.0 kb | Distal (>10kb) Multiome | 709 | |
| chr2:11,540,555–11,540,748 | 2.0 kb | Proximal (<10kb) | 107 | |
| chr2:11,542,554–11,543,068 | at TSS | At TSS | 212 | |
| chr2:11,550,790–11,551,875 | 69.1 kb | Distal (>10kb) Multiome HiCAR | 171 | |
| chr2:11,559,501–11,560,048 | 77.5 kb | Distal (>10kb) Multiome HiCAR | 146 | |
| chr2:11,582,389–11,583,691 | 100.9 kb | Distal (>10kb) Multiome HiCAR | 543 | |
| chr2:11,669,487–11,670,376 | 187.6 kb | Distal (>10kb) Multiome | 805 | |
| chr2:11,681,868–11,682,525 | 199.8 kb | Distal (>10kb) Multiome | 347 | |
| chr2:11,688,209–11,688,714 | 206.2 kb | Distal (>10kb) Multiome | 452 | |
| chr2:11,713,852–11,714,367 | 231.7 kb | Distal (>10kb) Multiome | 75 | |
| chr2:11,743,889–11,745,399 | 261.9 kb | Distal (>10kb) Multiome | 874 | |
| chr2:11,745,980–11,747,523 | 264.3 kb | Distal (>10kb) Multiome | 809 | |
| chr2:11,753,406–11,754,790 | 271.8 kb | Distal (>10kb) Multiome | 402 |
Genomic view of the GREB1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.