Enables identical protein binding activity. Located in cytoplasmic microtubule. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for GRAMD2B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GRAMD2B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GRAMD2B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:124,776,698–124,777,163 | 1646.5 kb | Distal (>10kb) Multiome HiCAR | 47 | |
| chr5:126,317,233–126,317,918 | 105.8 kb | Distal (>10kb) Multiome | 47 | |
| chr5:126,368,229–126,369,139 | 54.8 kb | Distal (>10kb) Multiome | 331 | |
| chr5:126,422,966–126,423,868 | 34 bp | At TSS Multiome | 621 | |
| chr5:126,591,477–126,591,957 | 168.3 kb | Distal (>10kb) Multiome | 61 | |
| chr5:126,594,453–126,595,707 | 171.9 kb | Distal (>10kb) Multiome | 803 | |
| chr5:126,599,987–126,601,746 | 177.5 kb | Distal (>10kb) Multiome | 911 | |
| chr5:126,674,036–126,674,611 | 250.9 kb | Distal (>10kb) Multiome | 99 | |
| chr5:126,718,055–126,718,948 | 295.1 kb | Distal (>10kb) Multiome | 184 |
Genomic view of the GRAMD2B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.