Predicted to enable cholesterol binding activity; cholesterol transfer activity; and phospholipid binding activity. Predicted to be involved in cellular response to cholesterol; cholesterol homeostasis; and intracellular sterol transport. Located in endoplasmic reticulum membrane; endoplasmic reticulum-plasma membrane contact site; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for GRAMD1B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GRAMD1B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GRAMD1B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:123,108,059–123,109,666 | 400.7 kb | Distal (>10kb) Multiome HiCAR | 58 | |
| chr11:123,166,097–123,166,614 | 343.6 kb | Distal (>10kb) Multiome | 131 | |
| chr11:123,168,860–123,170,139 | 339.9 kb | Distal (>10kb) Multiome | 127 | |
| chr11:123,194,428–123,196,820 | 313.6 kb | Distal (>10kb) Multiome | 388 | |
| chr11:123,261,339–123,261,812 | 248.3 kb | Distal (>10kb) Multiome | 295 | |
| chr11:123,301,675–123,302,413 | 208.0 kb | Distal (>10kb) Multiome HiCAR | 385 | |
| chr11:123,407,267–123,408,735 | 102.0 kb | Distal (>10kb) Multiome | 340 | |
| chr11:123,429,772–123,431,342 | 79.7 kb | Distal (>10kb) Multiome | 483 | |
| chr11:123,434,908–123,435,335 | 4.6 kb | Proximal (<10kb) | 104 | |
| chr11:123,438,158–123,438,461 | 7.9 kb | Proximal (<10kb) | 88 | |
| chr11:123,506,060–123,506,334 | 3.6 kb | Proximal (<10kb) | 74 | |
| chr11:123,509,594–123,510,296 | 71 bp | At TSS Multiome | 137 | |
| chr11:123,511,179–123,511,534 | 1.3 kb | Proximal (<10kb) | 275 | |
| chr11:123,580,414–123,581,089 | 70.8 kb | Distal (>10kb) Multiome | 383 | |
| chr11:123,640,646–123,641,369 | 131.2 kb | Distal (>10kb) Multiome | 228 | |
| chr11:123,653,549–123,655,224 | 144.8 kb | Distal (>10kb) Multiome | 617 | |
| chr11:123,740,865–123,741,879 | 231.6 kb | Distal (>10kb) Multiome | 789 | |
| chr11:123,741,997–123,743,161 | 232.8 kb | Distal (>10kb) Multiome | 370 | |
| chr11:123,775,088–123,776,113 | 265.6 kb | Distal (>10kb) Multiome | 148 | |
| chr11:123,796,181–123,796,630 | 286.6 kb | Distal (>10kb) Multiome | 36 |
Genomic view of the GRAMD1B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.