Predicted to be involved in neuron projection development. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for GPRIN2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GPRIN2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GPRIN2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:45,249,912–45,250,539 | 1306.7 kb | Distal (>10kb) Multiome HiCAR | 197 | |
| chr10:46,228,286–46,229,571 | 327.2 kb | Distal (>10kb) Multiome HiCAR | 447 | |
| chr10:46,282,489–46,283,279 | 273.7 kb | Distal (>10kb) Multiome | 160 | |
| chr10:46,284,312–46,285,217 | 271.9 kb | Distal (>10kb) Multiome | 616 | |
| chr10:46,540,658–46,543,680 | 15.3 kb | Distal (>10kb) Multiome HiCAR | 351 | |
| chr10:46,546,515–46,547,286 | 9.4 kb | Proximal (<10kb) | 74 | |
| chr10:46,547,405–46,547,864 | 8.8 kb | Proximal (<10kb) | 49 | |
| chr10:46,549,327–46,549,694 | 7.0 kb | Proximal (<10kb) | 94 | |
| chr10:46,551,153–46,551,778 | 4.9 kb | Proximal (<10kb) | 46 | |
| chr10:46,555,197–46,559,190 | 334 bp | At TSS Multiome | 519 | |
| chr10:46,565,680–46,565,877 | 9.0 kb | Proximal (<10kb) | 41 | |
| chr10:47,553,175–47,553,705 | 996.8 kb | Distal (>10kb) Multiome HiCAR | 425 | |
| chr10:48,444,253–48,445,663 | 1887.9 kb | Distal (>10kb) Multiome HiCAR | 245 | |
| chr10:48,523,248–48,524,705 | 1967.7 kb | Distal (>10kb) Multiome HiCAR | 466 |
Genomic view of the GPRIN2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.